AI Article Synopsis
- The study analyzed HBV genotypes in 97 positive subjects, revealing genotype D in 80.4% of cases and genotype E in 6.2%, along with A, B, and C, plus a new combination of D and G.
- Among 12 untreated individuals, 25% had HBV strains resistant to lamivudine and/or famciclovir, indicating the presence of drug-resistant mutants in untreated chronically infected patients in Italy.
- The findings enhance understanding of HBV diversity and the prevalence of drug resistance in the population.
Article Abstract
HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects.
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