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Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route.
Macromol Biosci
January 2025
Department of Pediatrics, Afyonkarahisar Health Sciences University, Afyonkarahisar, 03030, Türkiye.
Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, the pulmonary (INH) route is the other choice for inhalable formulations. In the study, biochemical and histological parameters of Cabazitaxel (CBZ) free (2 mg kg) and nanoparticle (NP) (2 mg kg CBZ equivalent) formulations are investigated after IV and INH administration in rats.
View Article and Find Full Text PDFSynergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.
Nanomedicine (Lond)
January 2025
Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla Istanbul, Turkey.
Aims: This study aims to develop a piezoelectric drug delivery system based on hexagonal boron nitride nanosheets (hBNs).
Materials And Methods: hBNs were synthesized using the chemical vapor deposition (CVD) method and characterized through imaging and spectroscopic techniques. Their piezoelectric properties were evaluated to confirm their functionality.
Versatile nanomaterials used in combatting biofilm infections.
Nanomedicine (Lond)
January 2025
Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Microbial infections are a pressing global health issue, exacerbated by the rise of antibiotic-resistant bacteria due to widespread antibiotic overuse. This resistance diminishes the effectiveness of current treatments, intensifying the need for new antimicrobial agents and innovative drug delivery strategies. Nanotechnology presents promising solutions, leveraging the unique properties of nanomaterials such as tunable optical and electronic characteristics, nanoscale size, and high surface-to-volume ratios.
View Article and Find Full Text PDFRadioresistance in rectal cancer: can nanoparticles turn the tide?
Mol Cancer
January 2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade Do Porto, Rua Alfredo Allen 208, Porto, 4200‑135, Portugal.
Rectal cancer accounts for over 35% of the worldwide colorectal cancer burden representing a distinctive subset of cancers from those arising in the colon. Colorectal cancers exhibit a continuum of traits that differ with their location in the large intestine. Due to anatomical and molecular differences, rectal cancer is treated differently from colon cancer, with neoadjuvant chemoradiotherapy playing a pivotal role in the control of the locally advanced disease.
View Article and Find Full Text PDFSupramolecular polymers: A perspective on the stability, biocompatibility and regulatory aspects.
Int J Pharm
January 2025
Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Hyderabad Telangana India. Electronic address:
Supramolecular polymers represent a distinctive class of polymers exhibiting similarities with covalent polymers, while also showcasing distinctive attributes such as responsiveness, reversibility, self-healing, and dynamism, which are conferred upon them by non-covalent interactions including hydrogen bonding, electrostatic interactions, van der Waals forces, π-π arrangements, and donor-acceptor interactions, among others. The noteworthy features of these supramolecular polymers have attracted considerable interest across diverse fields of science and technology, spanning electrochemistry, environmental science, drug delivery and tissue engineering. Nonetheless, the prevailing research focus in the realm of supramolecular polymers revolves around the advancement of novel methodologies aimed at synthesizing a broad spectrum of polymers characterized by diverse topologies.
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