Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea nudicaulis. Their structures have been assigned as 3beta-hydroxy-urs-11-ene (1) and 3beta-acetyl-urs-11-ene (2), respectively, by extensive NMR studies. In addition, olean-11,13(18)-diene (3), 3beta-hydroxy-13(28)-epoxy-urs-11-ene (4) and 3-keto-13(28)-epoxy-urs-11-ene (5) are also reported for the first time from this species.
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Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes.
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Wood Chemistry Laboratory, Department of Wood Sciences , Université Laval, 1045 Québec G1 V 0A6 , Canada.
Four new Δ ursene-type pentacyclic triterpenes containing the trans-feruloyl moiety (1-4), along with ursolic acid (5), were isolated from a Myrianthus arboreus root bark ethanol extract, after bioassay-guided subfractionation of its hexane fraction. The structures of 1-4 were established on the basis of the results of standard spectroscopic analytical methods (IR, HRESIMS, GC-MS, 1D and 2D NMR). The compounds 3β- O- trans-feruloyl-2α,19α-dihydroxyurs-12-en-28-oic acid (1), 2α-acetoxy-3β- O- trans-feruloyl-19α-hydroxyurs-12-en-28-oic acid (3), and 5 were determined to decrease the activity of hepatocellular glucose-6-phosphatase (G6Pase) and to activate glycogen synthase (GS).
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Magn Reson Chem
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International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, 75270-Karachi, Pakistan.
Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea nudicaulis. Their structures have been assigned as 3beta-hydroxy-urs-11-ene (1) and 3beta-acetyl-urs-11-ene (2), respectively, by extensive NMR studies. In addition, olean-11,13(18)-diene (3), 3beta-hydroxy-13(28)-epoxy-urs-11-ene (4) and 3-keto-13(28)-epoxy-urs-11-ene (5) are also reported for the first time from this species.
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Fitoterapia
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H.E.J. Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakista.
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