AI Article Synopsis
- The study aimed to explore the relationship between APOE gene variants and aortic stenosis (AS) using a large sample of patients with AS and healthy controls.
- Patients were assessed for heart disease symptoms and risk factors, while their APOE alleles were analyzed through genetic testing.
- The findings indicated that the presence of the APOE e4 allele does not have a significant association with AS, suggesting that the genetic influences on coronary artery disease (CAD) and AS may differ.
Article Abstract
Objectives: To analyse the association of APOE alleles with aortic stenosis (AS) in a large study population.
Methods: Patients with AS (n = 538) and a control group of the same age without heart disease (n = 536) were recruited. Left heart catheterisation was performed and mean gradient, aortic valve area, presence of stenotic coronary artery disease (CAD) and cardiovascular risk factors (hypercholesterolaemia, hypertension, smoking, diabetes mellitus and family history of CAD) were assessed. The frequency of the APOE major alleles e2, e3 and e4 was assessed by genotyping the polymorphisms APOE334 and APOE472 with a 5' exonuclease assay (TaqMan).
Results: Mean gradient across the aortic valve in cases was 50 (SD 20) mm Hg corresponding to a mean aortic valve area of 0.84 (SD 0.34) cm(2). 270 patients with AS had stenotic CAD. Among patients with AS, the prevalence of hypercholesterolaemia (64% v 40%, p < 0.001), smoking (43% v 27%, p < 0.001), diabetes (27% v 17%, p < 0.01), family history of CAD (30% v 21%, p 0.10).
Conclusion: APOE e4 is not associated with AS, reflecting the different genetic backgrounds of CAD and AS.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861026 | PMC |
| http://dx.doi.org/10.1136/hrt.2005.075317 | DOI Listing |
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