A multimode uncertainty relation (generalizing the Robertson-Schrödinger relation) is derived as a necessary constraint on the second moments of n pairs of canonical operators. In turn, necessary conditions for the separability of multimode continuous variable states under (m+n)-mode bipartitions are derived from the uncertainty relation. These conditions are proven to be necessary and sufficient for (1+n)-mode Gaussian states and for (m+n)-mode bisymmetric Gaussian states.
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