Spinal cord injuries are be potentially devastating. Despite initial presentation, they may be permanent or transient. A small percentage of spinal cord patients with motor or sensory dysfunction recover rapidly and completely with no neurological sequelae. Cervical cord neurapraxia is a frequent cause of transient neurologic symptoms. This transient neurological phenomenon involves bilateral motor paralysis and/or sensory manifestations that appear in the absence of any structural deficiencies of the cervical spine as evidence by negative diagnostic imaging. All patients with any history of neurologic deficits should be assessed thoroughly and rendered care appropriately to avoid secondary injury. This article will present a case study of a 15-year-old high school football player who complained of motor and sensory deficits after tackling another player. Treatment was provided and his neurological symptoms resolved completely. The pathophysiology of cellular injury related to the spinal cord and cervical cord neurapraxia is reviewed. In addition treatment modalities such as high dose steroids to reduce secondary spinal cord injury are discussed.
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http://dx.doi.org/10.1097/00043860-200512040-00006 | DOI Listing |
World Neurosurg
December 2024
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
J Pediatr Surg
December 2024
Children's Hospital New Orleans, Department of Surgery, New Orleans LA 70118, USA; Louisiana State University Health Sciences Center, Department of Surgery, Division of Pediatric Surgery, New Orleans LA 70112, USA. Electronic address:
Introduction: Traumatic injury is the leading cause of pediatric mortality and morbidity in the United States. While behavioral impairments of children after traumatic brain injury (TBI) have been described, outcomes following traumatic spinal cord injury (SCI) and multi-trauma (MT) are less known. We aimed to address the prevalence of behavioral and neuropsychiatric disorders in pediatric and adolescent trauma patients.
View Article and Find Full Text PDFMult Scler Relat Disord
December 2024
Laboratory of Nuclear Medicine (LIM43), Department of Radiology and Oncology, Faculdade de Medicina-FMUSP, Universidade de São Paulo, São Paulo 05403-911, SP, Brazil. Electronic address:
Background: Multiple sclerosis (MS) is divided into Relapsing-Remitting (RRMS) and Progressive (PMS) phenotypes, both associated with spinal cord (SC) damage. MS-related disability and SC atrophy are not yet fully understood and can differ across phenotypes. A combined approach using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) could provide a broader understanding of myelin changes in the cervical SC (CSC) in different MS phenotypes and the associations with disability.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
December 2024
Institute of Continuum Mechanics and Biomechanics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Dr.-Mack-Straße 81, Fürth, 90762, Germany. Electronic address:
The mechanical properties of brain and spinal cord tissue have proven to be extremely complex and difficult to assess. Due to the heterogeneous and ultra-soft nature of the tissue, the available literature shows a large variance in mechanical parameters derived from experiments. In this study, we performed a series of indentation experiments to systematically investigate the mechanical properties of porcine spinal cord tissue in terms of their sensitivity to indentation tip diameter, loading rate, holding time, ambient temperature along with cyclic and oscillatory dynamic loading.
View Article and Find Full Text PDFCell Rep
December 2024
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Development, Disease, Models, and Therapeutics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Astrocytes exhibit diverse cellular and molecular properties across the central nervous system (CNS). Recent studies identified region-specific transcription factors (TF) that oversee these diverse properties; how sex differences intersect with region-specific transcriptional programs to regulate astrocyte function is unknown. Here, we show that the TF Nkx6.
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