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Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial.
Lancet
July 2024
Bristol Medical School, University of Bristol, Bristol, UK.
Background: Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness. The first-line therapy is anti-vascular endothelial growth factor (anti-VEGF) agents delivered by intravitreal injection. Ionising radiation mitigates key pathogenic processes underlying nAMD, and therefore has therapeutic potential.
View Article and Find Full Text PDFVitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative Age-Related macular degeneration (TIGER): study protocol for a phase 3, pan-European, two-group, non-commercial, active-control, observer-masked, superiority, randomised controlled surgical trial.
Trials
January 2022
Population Health Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Background: Neovascular (wet) age-related macular degeneration (AMD) can be associated with large submacular haemorrhage (SMH). The natural history of SMH is very poor, with typically marked and permanent loss of central vision in the affected eye. Practice surveys indicate varied management approaches including observation, intravitreal anti-vascular endothelial growth factor therapy, intravitreal gas to pneumatically displace SMH, intravitreal alteplase (tissue plasminogen activator, TPA) to dissolve the clot, subretinal TPA via vitrectomy, and varying combinations thereof.
View Article and Find Full Text PDFIndividual differences in crowding predict visual search performance.
J Vis
May 2021
Cognitive Psychology, Institute for Brain and Behavior, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Visual search is an integral part of human behavior and has proven important to understanding mechanisms of perception, attention, memory, and oculomotor control. Thus far, the dominant theoretical framework posits that search is mainly limited by covert attentional mechanisms, comprising a central bottleneck in visual processing. A different class of theories seeks the cause in the inherent limitations of peripheral vision, with search being constrained by what is known as the functional viewing field (FVF).
View Article and Find Full Text PDFFlexible Working Memory Through Selective Gating and Attentional Tagging.
Neural Comput
January 2021
Faculty of Behavior and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Noord Holland, The Netherlands, Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
Working memory is essential: it serves to guide intelligent behavior of humans and nonhuman primates when task-relevant stimuli are no longer present to the senses. Moreover, complex tasks often require that multiple working memory representations can be flexibly and independently maintained, prioritized, and updated according to changing task demands. Thus far, neural network models of working memory have been unable to offer an integrative account of how such control mechanisms can be acquired in a biologically plausible manner.
View Article and Find Full Text PDFAttention for action in visual working memory.
Cortex
October 2020
Department Vision & Cognition, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands; Department Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, the Netherlands; Department of Psychiatry, Academic Medical Center, Amsterdam UMC, the Netherlands.
From the conception of Baddeley's visuospatial sketchpad, visual working memory and visual attention have been closely linked concepts. An attractive model has advocated unity of the two cognitive functions, with attention serving the active maintenance of sensory representations. However, empirical evidence from various paradigms and dependent measures has now firmly established an at least partial dissociation between visual attention and visual working memory maintenance - thus leaving unclear what the relationship between the two concepts is.
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