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Lay views in Southern France of the acceptability of refusing to provide treatment because of alleged futility.
BMC Med Ethics
January 2025
Ethics and Work Research Unit, Institute of Advanced Studies (EPHE), Paris, France.
Aim: To carry out a detailed study of existing positions in the French public of the acceptability of refusing treatment because of alleged futility, and to try to link these to people's age, gender, and religious practice.
Method: 248 lay participants living in southern France were presented with 16 brief vignettes depicting a cancer patient at the end of life who asks his doctor to administer a new cancer treatment he has heard about. Considering that this treatment is futile in the patient's case, the doctor refuses to prescribe it.
Multi-objective optimization of the heating oil circuit inside the calendering roller for the lithium battery pole piece.
Sci Rep
January 2025
Xingtai Naknor Technology Co., Ltd, Xingtai, 054000, China.
The heating oil circuit plays an essential role in the heating calendering roller for the lithium battery pole piece. To achieve the optimization of the heating oil circuit, a fluid-thermal-structural coupling method and a multi-objective optimization procedure are proposed to obtain the optimal solution. A fluid-thermal-structural coupling flowchart based on the numerical modeling for the calendering roller temperature distribution is created to automate the analysis processes in the optimization iteration.
View Article and Find Full Text PDFMPEMDA: A Multi-Similarity Integration Approach with Pre-completion and Error Correction for Predicting Microbe-Drug Associations.
Methods
January 2025
School of Computer Science and Engineering, Central South University, Changsha 410083, China; Hunan Provincial Key Lab on Bioinformatics, Central South University, Changsha 410083, China.
Exploring the associations between microbes and drugs offers valuable insights into their underlying mechanisms. Traditional wet lab experiments, while reliable, are often time-consuming and labor-intensive, making computational approaches an attractive alternative. Existing similarity-based machine learning models for predicting microbe-drug associations typically rely on integrated similarities as input, neglecting the unique contributions of individual similarities, which can compromise predictive accuracy.
View Article and Find Full Text PDFContemporary Approach to the Diagnosis and Classification of Intestinal T-cell Lymphomas.
Hum Pathol
January 2025
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
We provide an overview of recent advances in the diagnosis and classification of intestinal T- and NK-cell lymphomas and lymphoproliferative disorders that primarily involve the gastrointestinal (GI) tract. It should be mentioned that systemic T- and NK-cell lymphomas can present initially in the GI tract but are not the focus of this review. Here, we focus on the clinical and pathologic findings of enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, intestinal T-cell lymphoma not otherwise specified, indolent T-cell lymphoproliferative disorder of the GI tract and indolent NK-cell lymphoproliferative disorder of the GI tract (previously known as NK-cell enteropathy).
View Article and Find Full Text PDFAn integrated participatory framework for WEFE nexus strategic planning: The Jordan Valley case study.
J Environ Manage
January 2025
Department of Environmental Economics & Management, The Hebrew University of Jerusalem, Israel.
The Jordan Valley (JV) is a critical region where the interplay of water, energy, food, and ecosystem (WEFE) dynamics presents both challenges and opportunities for sustainable development and climate change mitigation and adaptation. In such a transboundary river basin with acute nexus problems and a long history of conflicts, it is essential that conscious efforts are made to pluralize the debate and actively encourage stakeholders' empowerment, participation and fair collaboration in strategic planning. An integrated framework for participatory strategic planning in the WEFE nexus is proposed, which has been developed in the context of the JV case study.
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