[Antagonism of vitamin E on lipid peroxidation in testis of male rats with carbon disulfide].

Objective: To study the antagonistic joint action of vitamin E (VE) lipid peroxidation of testis in the male rats with carbon disulfide (CS2).

Methods: 36 wistar male rats were randomly dicided into six groups. It took 10-week for the rats to breath CS2 in different concentrations (0, 50, 250 and 1250 mg/m3), respectively, CS2 (1250 mg/m3) with VE (250 mg/kg diet) and VE (250 mg/kg diet) group. After 10-week treatment, rats were killed and the following parameters of lipid peroxidation in testis were determined:SOD, MDA, GST, GSH, GSH-px, NO, NOS and iNOS.

Results: Compare with the control group, SOD, GST, GSH-px, NOS and iNOS activity were decreased (P < 0.05 or P < 0.01), GSH, NO content decreased also, MDA content was increased (P < 0.01). After the antioxidant VE treatmented, the parameters were significantly increased (the amount of MDA was decreased).

Conclusion: The antioxidant VE significantly protects against on lipid peroxidation in testes of male rats with CS2.