[structure: see text] Without employing protection and deprotection processes, two series of triazine-based dendrons were efficiently prepared by a convergent method and fully characterized; their physical properties, including acidic, thermal, electrical, and optical stabilities were also studied.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol0531076 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
1,3,5-Triazine as Branching Connector for the Construction of Novel Antimicrobial Peptide Dendrimers: Synthesis and Biological Characterization.
Int J Mol Sci
May 2024
School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, KwaZulu-Natal, South Africa.
Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and development displaying broad biological activity. Triazine-based dendrimers were fully synthesized in the solid phase, and their antimicrobial activity and some insights into their mechanisms of action were explored.
View Article and Find Full Text PDFMagnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery.
Sci Rep
November 2022
Institute of Nanosciences and Nanotechnology, Arak University, Arak, 38156-88349, Iran.
Nanoscale engineering is an efficient method for the treatment of multiple infectious diseases. Due to the controllable functionalities, surface properties, and internal cavities, dendrimer-based nanoparticles represent high performance in drug delivery, making their application attractive in pharmaceutical and medicinal chemistry. In this study, a dendritic nanostructure (FeO@SiO@TAD-G3) was designed and fabricated by grafting a triazine-based dendrimer on a magnetic nanomaterial.
View Article and Find Full Text PDFFirst-in-Class Star-Shaped Triazine Dendrimers Endowed with MMP-9 Inhibition and VEGF Suppression Capacity: Design, Synthesis, and Anticancer Evaluation.
ACS Omega
June 2022
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21321, Egypt.
Off-target side effects are major challenges hindering the clinical success of matrix metalloproteinase (MMP) inhibitors. Various targeting strategies revitalized MMP research to eliminate this drawback. Herein, we developed -triazine-based dendrimeric architecture not only amenable to tumor targeting but also decorated with pharmacophoric entities to endow MMP-9 inhibition for halting cancer progression.
View Article and Find Full Text PDFThermally Activated Delayed Fluorescent Dendrimers that Underpin High-Efficiency Host-Free Solution-Processed Organic Light-Emitting Diodes.
Adv Mater
June 2022
Organic Semiconductor Centre, EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK.
The development of high-performance solution-processed organic light-emitting diodes (OLEDs) remains a challenge. An effective solution, highlighted in this work, is to use highly efficient thermally activated delayed fluorescence (TADF) dendrimers as emitters. Here, the design, synthesis, density functional theory (DFT) modeling, and photophysics of three triazine-based dendrimers, tBuCz2pTRZ, tBuCz2mTRZ, and tBuCz2m2pTRZ, is reported, which resolve the conflicting requirements of achieving simultaneously a small ΔE and a large oscillator strength by incorporating both meta- and para-connected donor dendrons about a central triazine acceptor.
View Article and Find Full Text PDFConverting non-Mesogenic to Mesogenic Stacking of Amino--Triazine-Based Dendrons with -CN Phenyl Unit by Eliminating Peripheral Dipole.
Nanomaterials (Basel)
January 2022
Department of Chemistry, Tamkang University, No. 151, Yingzhuan Rd., New Taipei City 251, Taiwan.
Three new amino--triazine-based dendrons, , , and , containing an aryl-CN moiety in the dendritic skeleton were prepared in 72-81% yields (: R = - N(-CH), R = -OCH, : R = R = - N(-CH), : R = - N(-CH), R = - N(-CH)). Dendrons with N(-CH) and -OCH peripheral substituents, surprisingly, did not show any mesogenic phase during the thermal process. However, non-mesogenic can be converted to mesogenic or by eliminating the peripheral dipole arising from the alkoxy substituent; dendron only comprising the same N(-CH) peripheral groups showed a ~25 °C mesogenic range on heating and ~108 °C mesogenic range on cooling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!