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Chronic Pruritus: A Review.
JAMA
June 2024
Miami Itch Center, Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Article Synopsis
- - Chronic pruritus, or long-term itch lasting 6 weeks or more, affects about 22% of people, leading to poor sleep and decreased quality of life, though it represents only 1% of doctor visits.
- - The condition can be classified into inflammatory (60% of cases), neuropathic (25%), or other causes (15%), with common inflammatory triggers being eczema and psoriasis, while neuropathic issues may arise from nerve dysfunction.
- - Diagnosis often involves thorough history-taking and lab tests, with initial treatments typically being topical anti-inflammatory medications; if these fail, referral to a specialist or systemic treatments may be necessary.
β-Lactoglobulin variants as potential carriers of pramoxine: Comprehensive structural and biophysical studies.
J Mol Recognit
October 2023
Faculty of Biochemistry, Biophysics and Biotechnology, Department of Physical Biochemistry, Jagiellonian University, Kraków, Poland.
β-Lactoglobulin (BLG) is a member of the lipocalin family. As other proteins from this group, BLG can be modified to bind specifically compounds of medical interests. The aim of this study was to evaluate the role of two mutations, L39Y and L58F, in the binding of topical anesthetic pramoxine (PRM) to β-lactoglobulin.
View Article and Find Full Text PDFSkin nociceptive block with pramoxine delivery by subcutaneous injection in rats.
Pharmacol Rep
December 2018
Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Background: Pramoxine has been shown to produce spinal anesthesia, while cutaneous analgesia (peripheral) of pramoxine is not established. The experimental goal was to examine cutaneous antinociception produced by a local anesthetic (LA) pramoxine and compare this result with that of another well-known LA lidocaine.
Methods: Cutaneous antinociception was evaluated by blockade of pinprick- induced cutaneous trunci muscle reflex (CTMR) on the skin of rat's back.
Contact Dermatitis to Medications and Skin Products.
Clin Rev Allergy Immunol
February 2019
Department of Dermatology, Mayo Clinic, Phoenix, AZ, USA.
Consumer products and topical medications today contain many allergens that can cause a reaction on the skin known as allergic contact dermatitis. This review looks at various allergens in these products and reports current allergic contact dermatitis incidence and trends in North America, Europe, and Asia. First, medication contact allergy to corticosteroids will be discussed along with its five structural classes (A, B, C, D1, D2) and their steroid test compounds (tixocortol-21-pivalate, triamcinolone acetonide, budesonide, clobetasol-17-propionate, hydrocortisone-17-butyrate).
View Article and Find Full Text PDFUnlabelled:
Objective: To evaluate the speed of onset and duration of relief of two ceramide-containing formulations with 1% pramoxine hydroxide (CeraVe® Itch Relief Lotion and Cream,Valeant Pharmaceuticals North America LLC, Irvine, CA) in patients with atopic history, including those with active flare and the comparative efficacy of CeraVe Itch Relief Cream to hydrocortisone 1% cream and night-time itch relief with continued use.
Methods: Two double-blind, split-body, randomized studies in 66 male and female subjects, ages 11+ years, with history of atopic dermatitis (AD). Itch severity was assessed on a 10-point scale (where 0=none and 7-9=severe).
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