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WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome.
J Hematol Oncol
January 2025
Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.
Cell therapies, including tumor antigen-loaded dendritic cells used as therapeutic cancer vaccines, offer treatment options for patients with malignancies. We evaluated the feasibility, safety, immunogenicity, and clinical activity of adjuvant vaccination with Wilms' tumor protein (WT1) mRNA-electroporated autologous dendritic cells (WT1-mRNA/DC) in a single-arm phase I/II clinical study of patients with advanced solid tumors receiving standard therapy. Disease status and immune reactivity were evaluated after 8 weeks and 6 months.
View Article and Find Full Text PDFAwareness, knowledge, and attitudes of the Belgian general population towards paternal perinatal depression: a descriptive cross-sectional study.
Front Psychiatry
January 2025
Department of Public Health, Biostatistics and Medical Informatics Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Background: Paternal perinatal depression affects 10% of fathers, implying a significant burden on families and public health. A better insight into the population's health literacy could guide professionals and policymakers in addressing these men and making better use of existing healthcare options. It is also crucial for caregivers, as they play a vital role in identifying symptoms, encouraging help-seeking, and reducing stigma.
View Article and Find Full Text PDFTransition to Adult Care in Turner Syndrome: Research Gaps and Strategies for Achieving Success.
Am J Med Genet C Semin Med Genet
January 2025
Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Health care transition is a process by which children with chronic medical conditions gradually and purposefully move from pediatric to adult-centered health care systems. While transition guidelines have been published by multiple national and international organizations, transition processes have not been optimized for many populations, including youth with Turner syndrome (TS). Numerous barriers exist, at both the system and individual/family level.
View Article and Find Full Text PDFEfficient optimisation of physical reservoir computers using only a delayed input.
Commun Eng
January 2025
Laboratoire d'Information Quantique CP224, Université libre de Bruxelles (ULB), Av. F. D. Roosevelt 50, 1050, Bruxelles, Belgium.
Reservoir computing is a machine learning algorithm for processing time dependent data which is well suited for experimental implementation. Tuning the hyperparameters of the reservoir is a time-consuming task that limits is applicability. Here we present an experimental validation of a recently proposed optimisation technique in which the reservoir receives both the input signal and a delayed version of the input signal.
View Article and Find Full Text PDFDecentralized worker-centred occupational management in health care: nationwide survey and alpha testing.
Occup Med (Lond)
January 2025
Sciense, New York, NY 10013, USA.
Background: Occupational stress among healthcare workers negatively impacts job satisfaction and patient care quality, jeopardizing healthcare system sustainability. Traditional employer-driven approaches often fail to address these challenges comprehensively, leading to persistent gaps in work condition transparency and well-being.
Aims: To elucidate the working conditions of health workers and introduce a worker-centred, technology-based strategy moving beyond traditional practices and entrenched medical culture.
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