AI Article Synopsis
- The study aimed to investigate how the levels of platelet-activating factor acetylhydrolase (PAFah) in semen relate to sperm motility in men undergoing infertility treatment.
- Researchers collected semen samples from 312 men and measured both sperm motility and PAFah levels, using statistical analysis to determine their correlation.
- Results showed that higher PAFah levels were associated with lower sperm motility, indicating that PAFah may act as a factor that inhibits sperm function, while PAF could promote sperm function.
Article Abstract
Objective: To determine the relationship between platelet-activating factor acetylhydrolase (PAFah) content in semen and sperm motility.
Design: The PAFah levels in semen were measured and correlated with sperm motility.
Setting: Clinical laboratory in a private assistant reproductive technology clinic.
Patient(s): Three hundred and twelve men seeking diagnosis and treatment of infertility.
Intervention(s): Semen samples were collected from 312 healthy mature men seeking infertility treatment. Sperm motility and PAFah activity were measured in seminal plasma. Data was analyzed by Student's t test and regression analysis.
Main Outcome Measure(s): PAFah activity and sperm motility.
Result(s): Seminal PAFah content ranged from a low of 179 IU/L to a high of 2,457 IU/L. The overall mean PAFah content in semen was 780.59 IU/L. Linear regression analysis revealed a significant (R2 = 0.655) and negative relationship between PAFah content in semen and sperm motility. Semen specimens with high percent motility (> or = 50%) had significantly lower PAFah concentrations (442.03 +/- 14.37 IU/L) than those with the lower percent sperm motility (< 50%) (882.16 +/- 18.45 IU/L).
Conclusion(s): The data confirm the presence of PAFah in human semen and that activity is significantly and negatively correlated with sperm motility. The PAFah is proven to be a candidate for sperm decapacitation factors, whereas PAF is qualified to be a candidate for sperm capacitation factors.
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| http://dx.doi.org/10.1016/j.fertnstert.2005.07.1303 | DOI Listing |
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