AI Article Synopsis
- A new method has been created that allows for effective catalytic enantioselective insertions into O-H bonds.
- This method uses a copper/bisazaferrocene catalyst to combine alcohols (like 2-trimethylsilylethanol) with alpha-aryl-alpha-diazo esters.
- The result is a high yield and good enantiomeric excess (ee) in the reaction.
Article Abstract
The first effective method for catalytic enantioselective insertions into O-H bonds has been developed. Specifically, a copper/bisazaferrocene catalyst couples alcohols such as 2-trimethylsilylethanol with alpha-aryl-alpha-diazo esters in high yield and good ee.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517123 | PMC |
| http://dx.doi.org/10.1021/ja0607739 | DOI Listing |
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