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| http://dx.doi.org/10.1073/pnas.46.8.1053 | DOI Listing |
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Structure/function of ATP sulfurylase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthase (hPAPSS).
Biochem Biophys Rep
March 2025
College of Biomedical Sciences, Larkin University, Miami, FL, 33169, USA.
Article Synopsis
- PAPS is synthesized in two steps: first, ATP sulfurylase converts ATP into APS, then APS-kinase phosphorylates APS to produce PAPS.
- Mutations in the hPAPSS isoform1, particularly in histidine residues, disrupt the function of ATP sulfurylase without affecting APS-kinase.
- The N-K mutant exhibited improved catalytic efficiency for ATP and sulfate, indicating how specific residues can enhance enzyme activity and the importance of inter-domain interactions in the overall structure and function of hPAPSS1.
Transcriptome and metabolome analyses reveal the promoting effects of arbuscular mycorrhizal fungi on selenium uptake in grapevines.
Plant Physiol Biochem
December 2024
College of Horticulture, Sichuan Agricultural University, Chengdu, 611130, China. Electronic address:
To improve the selenium (Se) uptake in grapes, the effects of arbuscular mycorrhizal fungi (AMF) on the Se accumulation in grapevines were studied under a soil Se concentration of 5 mg/kg, and the transcriptome and metabolome sequencing were used to elucidate the regulatory mechanism of AMF on Se accumulation. AMF initially decreased the biomass of grapevines, but later increased the biomass. Moreover, AMF enhanced the activities of Se metabolism enzymes (adenosine triphosphate sulfurylase, adenosine 5'-phosphosulfate reductase, serine acetyltransferase, and cysteine methyltransferase) and the Se concentration in grapevines.
View Article and Find Full Text PDFAnalysis of the quadruple lsu mutant reveals molecular determinants of the role of LSU proteins in sulfur assimilation in Arabidopsis.
Plant J
December 2024
Laboratory of Plant Protein Homeostasis, Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.
Because plants are immobile, they have developed intricate mechanisms to sense and absorb nutrients, adjusting their growth and development accordingly. Sulfur is an essential macroelement, but our understanding of its metabolism and homeostasis is limited. LSU (RESPONSE TO LOW SULFUR) proteins are plant-specific proteins with unknown molecular functions and were first identified during transcriptomic studies on sulfur deficiency in Arabidopsis.
View Article and Find Full Text PDFenhances HS production in .
Gut Microbes
November 2024
Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Sulfate- and sulfite-reducing bacteria (SRB) are a group of strict anaerobes found within the human gut. , a sulfite-reducing bacterium which produces hydrogen sulfide (HS) from taurine and isethionate respiration, is a common member of the healthy commensal human gut microbiota but has been implicated in several disease states including inflammatory bowel disease and colorectal cancer. , one of the most prominent gut bacteria, has sulfatases which release sulfate, serving as a potential substrate for sulfate-reducing bacteria.
View Article and Find Full Text PDFGut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide.
Gut Microbes
September 2024
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Article Synopsis
- Cholestatic liver injury is caused by toxic bile acids and currently lacks effective treatments, but Andrographolide (AP) shows promise despite its poor oral bioavailability due to gut microbiota metabolism.
- Our research reveals that gut microbiota plays a crucial role in the metabolism of AP, specifically through the action of an enzyme called APS reductase, which impacts AP's effectiveness against cholestasis.
- By inhibiting APS reductase, we found that AP's bioavailability and anti-cholestatic properties improve, and AP may help reduce bile acid levels by activating the FXR pathway, leading to new strategies for its clinical use in treating liver injury.
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