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http://dx.doi.org/10.1073/pnas.24.3.145 | DOI Listing |
Viruses
December 2024
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
(TYLCV) poses a significant threat to tomato production, leading to severe yield losses. The current control strategies primarily rely on the use of pesticides, which are often nonselective and costly. Therefore, there is an urgent need to identify more environmentally friendly alternatives.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
DPP4 is an enzyme with multiple natural substrates and probable involvement in various mechanisms. It constitutes a drug target for the treatment of diabetes II, although, also related to other disorders. While a number of drugs with competitive inhibitory action and covalent binding capacity are available, undesired side effects exist partly attributed to drug kinetics, and research for finding novel, potent, and safer compounds continues.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led to a better understanding of EPN subtypes and revealed a critical role of oncogenes ZFTA-RELA fusion and EPHB2 in supratentorial ependymoma (ST-EPN). However, the immune system's role in tumor progression and response to therapy remains poorly understood.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Departamento de Medio Ambiente y Agronomía, INIA-CSIC, Carretera de A Coruña km. 7.5, 28040, Madrid, Spain. Electronic address:
Background: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analytical methods. In parallel, the use of miniaturized methods and sustainable solvents in sample preparation is highly recommended. Accordingly, in this work, a 3D-printed millifluidic device was designed and used for the on-line natural deep eutectic solvent (NADES)-based liquid phase microextraction (LPME) coupled to a spectrofluorometer for, as a proof of concept, the determination of thiabendazole (TBZ) in fruit juice samples.
View Article and Find Full Text PDFAnticancer Agents Med Chem
January 2025
Department of Chemistry, Faculty of Science, Cairo University, A. R, Egypt.
Background: Xanthene derivatives are a notable class of heterocyclic compounds widely studied for their significant biological impact. These molecules, found in both natural and synthetic forms, have attracted substantial scientific interest due to their broad spectrum of biological activities. The xanthene nucleus, in particular, is associated with a range of potential pharmaceutical properties, including antibacterial, antiviral, antiinflammatory, anticancer, and antioxidant effects.
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