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Antioxidant, anti-prostate cancer potential, and phytochemical composition of the ethyl acetate stem bark extract of Boascia coriacea (Pax.).
PLoS One
December 2024
Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya.
Background: The antioxidant and anticancer potential of natural compounds, particularly from medicinal plants, is increasingly being explored as alternatives to synthetic antioxidants and chemotherapeutics. Boascia coriacea (Pax) has been traditionally used for treating various ailments, including oxidative stress-related diseases and prostate cancer. However, there is a paucity of empirical evidence to validate the ethnomedicinal claims, hence this study.
View Article and Find Full Text PDFRNA-seq analysis reveals genes associated with Macrophomina phaseolina-induced host senescence in soybean.
BMC Genomics
November 2024
Department of Plant Pathology, Kansas State University, Manhattan, KS, 66506, USA.
Article Synopsis
- Charcoal rot, caused by the fungus Macrophomina phaseolina, is a significant threat to soybean crops, particularly in the Midwest USA, making resistance breeding challenging due to the complex interactions at the molecular level.
- A study found that pre-treating soybeans with L-ascorbic acid (LAA) before the fungus infection reduced the severity of the disease by influencing gene expression related to stress responses and photosynthesis.
- The research identified that while many genes were down-regulated during the fungus attack, LAA treatment could boost certain protective genes, highlighting the intricate relationship between plant defense mechanisms and the pathogen's impact.
Protective Effects of Ascorbic Acid Against Cadmium-Induced Toxicity in the Placenta and Fetus of Rats.
J Biochem Mol Toxicol
November 2024
Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
This study aimed to determine the protective role of l-ascorbic acid in a pregnant rat model of cadmium-induced toxicity. Cadmium is a toxic heavy metal that can seriously harm placenta and fetus tissue in pregnant women. Forty-two healthy female Wistar albino rats (250-300 g weight and 14-16 weeks) were randomly distributed into six equal groups (n = 7): control, cadmium 1 mg (CD1), cadmium 5 mg (CD5), ascorbic acid (AA), CD1+AA, CD5+AA.
View Article and Find Full Text PDFHuman prolyl hydroxylase domain 2 reacts with O and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes.
Sci Rep
October 2024
Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation. We report crystallographic, spectroscopic, and biochemical characterization of stable and inactive PHD2.
View Article and Find Full Text PDFL-gulono-γ-lactone Oxidase, the Key Enzyme for L-Ascorbic Acid Biosynthesis.
Curr Issues Mol Biol
October 2024
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawińskiego 5A, 02-106 Warsaw, Poland.
L-ascorbic acid (AsA, vitamin C) plays a vital role in preventing various diseases, particularly scurvy. AsA is known for its antioxidant properties, which help protect against reactive oxygen species generated from metabolic activities; however, at high doses, it may exhibit pro-oxidative effects. The final step in AsA biosynthesis is catalyzed by L-gulono-γ-lactone oxidase (GULO).
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