AI Article Synopsis
- A series of non-nucleoside compounds (9-47) were created through a multi-step synthesis process that involved initial reactions with formic acid.
- Compounds 1-4 were transformed into compounds 5-8 before being reacted with various alkyl halides (like bromides and chlorides) in the presence of sodium hydride (NaH) using dry DMF as a solvent.
- The final compounds (9-47) were then tested for their effectiveness against the herpes simplex virus type-II (HSV-II).
Article Abstract
A series of non-nucleosides 9-47 were synthesized. Compounds 1-4 were reacted with formic acid (85%) to afford compounds 5-8. Then, the latter compounds were reacted with alkyl halides a-f (2-bromopropane, 2-bromobutane, benzyl bromide, benzyl chloromethyl ether, chloromethyl ethyl ether, phenacyl bromide) in the presence of NaH in dry DMF to give the desired compounds 9-47, which were evaluated for activity against herpes simplex virus type-II (HSV-II).
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| http://dx.doi.org/10.1002/ardp.200500162 | DOI Listing |
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