Optical tomography of gel dosimeters is a promising and cost-effective avenue for quality control of radiotherapy treatments such as intensity-modulated radiotherapy (IMRT). Systems based on a laser coupled to a photodiode have so far shown the best results within the context of optical scanning of radiosensitive gels, but are very slow ( approximately 9 min per slice) and poorly suited to measurements that require many slices. Here, we describe a fast, three-dimensional (3D) optical computed tomography (optical-CT) apparatus, based on a broad, collimated beam, obtained from a high power LED and detected by a charged coupled detector (CCD). The main advantages of such a system are (i) an acquisition speed approximately two orders of magnitude higher than a laser-based system when 3D data are required, and (ii) a greater simplicity of design. This paper advances our previous work by introducing a new design of focusing optics, which take information from a suitably positioned focal plane and project an image onto the CCD. An analysis of the ray optics is presented, which explains the roles of telecentricity, focusing, acceptance angle and depth-of-field (DOF) in the formation of projections. A discussion of the approximation involved in measuring the line integrals required for filtered backprojection reconstruction is given. Experimental results demonstrate (i) the effect on projections of changing the position of the focal plane of the apparatus, (ii) how to measure the acceptance angle of the optics, and (iii) the ability of the new scanner to image both absorbing and scattering gel phantoms. The quality of reconstructed images is very promising and suggests that the new apparatus may be useful in a clinical setting for fast and accurate 3D dosimetry.
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http://dx.doi.org/10.1088/0031-9155/51/8/007 | DOI Listing |
Biotechnol Appl Biochem
January 2025
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Globally, breast cancer continues to be the leading type of cancer affecting women, with rising mortality rates projected by 2030. This highlights the importance of developing new, affordable treatments, like drug delivery systems that use nanoparticles. Gold nanoparticles (AuNPs), including their exceptional optical and physical attributes, make them an attractive vehicle for targeted treatment, allowing for accurate and focused delivery of medication directly to cancerous cells while reducing harmful side effect.
View Article and Find Full Text PDFAnal Chim Acta
January 2025
Hubei Provincial Key Laboratory of Green Materials for Light Industry, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, 430068, PR China. Electronic address:
Background: Accurate monitoring glucose level is significant for human health management, especially in the prevention, diagnosis, and management of diabetes. Electrochemical quantification of glucose is a convenient and rapid detection method, and the crucial aspect in achieving great sensing performance lies in the selection and design of the electrode material. Among them, CuO, with highly catalysis ability, is commonly used as electrocatalyst in non-enzymatic glucose sensing.
View Article and Find Full Text PDFRetina
December 2024
Pediatrics Department. Alvaro Cunqueiro University Hospital, 36313 Vigo, Spain. Galicia Sur Health Research Institute.
Purpose: Focusing the premature birth and its potential complications, this study analyzes Foveal Avascular Zone (FAZ) measured by Optical Coherence Tomography Angiography (OCTA) and its correlation with the severity of prematurity and neonatal growth.
Methods: A cross-sectional comparative study was performed, involving 71 children school-age with history of prematurity and a full-term children control group. Several variables from the neonatal period were collected, such as Gestational Age (GA), Birth Weight (BW), initial Weight Gain (WG) and Retinopathy of Prematurity (ROP).
Eye Contact Lens
December 2024
Department of Ophthalmology (E.D., Z.B.S., E.E.E.O., H.O.), Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalçin City Hospital, Istanbul, Turkey; Goztepe Prof. Dr. Suleyman Yalçin City Hospital (O.F.Y.), Department of Ophthalmology, Istanbul, Turkey; and Haydarpasa Numune Education and Research Hospital (M.S.M.), University of Health Sciences, Sadik Eratik Eye Institute, Istanbul, Turkey.
Objectives: This study compares the cosmetic and functional outcomes of corneal tattooing/keratopigmentation and ocular prostheses in rehabilitating disfigured eyes, focusing on esthetic appearance and emotional well-being.
Methods: Ninety-two patients were included: 48 received corneal tattooing, and 44 were fitted with ocular prostheses. Anophthalmic surgery was indicated for trauma, painful blind eye, endophthalmitis, tumor, and corneal ulcer, while corneal tattooing was performed for trauma, corneal ulcer, and endophthalmitis.
Psychol Rev
January 2025
Department of Psychological and Brain Sciences, Dartmouth College.
Our premodern ancestors had perceptual, motoric, and cognitive functional domains that were modularly encapsulated. Some of these came to interact through a new type of cross-modular binding in our species. This allowed previously domain-dedicated, encapsulated motoric and sensory operators to operate on operands for which they had not evolved.
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