Study Design: In this retrospective radiography study, we analyzed curve shape and direction in scoliosis secondary to neuromuscular disease.
Objective: To determine if in different types of neuromuscular scoliosis a predominant curve pattern can be found and if similarities with idiopathic scoliosis exist.
Summary Of Background Data: To the authors' knowledge, systematic analysis of curve patterns in patients with neuromuscular scoliosis has not been performed in a group of this size and composition.
Methods: Spinal full-length radiographs of 198 patients with neuromuscular scoliosis were analyzed for curve shape and direction. Patients were divided into 4 groups consisting of Duchenne muscular dystrophy, cerebral palsy, spinal muscular atrophy, and spina bifida.
Results: The results of this study show a predominance of right-sided thoracic and thoracolumbar curves, and left-sided lumbar curves, which differed significantly from an equal right-left distribution. Apical levels were respectively at T8, T12/L1 disc, and L2.
Conclusion: In neuromuscular scoliosis, curve patterns and apical levels are similar to what is seen in the most prevalent types of adolescent idiopathic scoliosis.
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http://dx.doi.org/10.1097/01.brs.0000208131.42824.c3 | DOI Listing |
Rev Esp Patol
January 2025
Laboratory of Genomics and Human Genetics, Pasteur Institute of Morocco, Casablanca, Morocco. Electronic address:
Early-onset Myopathy, Areflexia, Respiratory Distress and Dysphagia (EMARDD) is a congenital neuromuscular disease with a progressive muscle weakness, respiratory failure, joint contractures, and scoliosis without any symptoms of functional brain anomalies caused by variants in the MEGF10 gene. Here, we report the clinical phenotype and genetic features of a Moroccan patient who carries a novel variant associated with EMARDD on the MEGF10 gene. The Whole Exome Sequencing analysis conducted on a 11 year old boy with respiratory and swallowing difficulties revealed the presence of the novel variant c.
View Article and Find Full Text PDFSpine Deform
January 2025
Department of Orthopaedic Surgery, Scottish Rite Hospital for Children, Dallas, TX, USA.
Purpose: The etiology of early-onset scoliosis (EOS) has been shown to significantly influence baseline parent-reported health-related quality of life (HrQOL). In combining these etiology groups, we obligatorily lump together many disparate diagnoses, particularly true in the neuromuscular (NM) cohort. We sought to evaluate the influence of underlying neuromuscular diagnosis on the HrQOL at 5 years following surgery for EOS.
View Article and Find Full Text PDFGlobal Spine J
January 2025
Department of Orthopaedics, University Clinic Heidelberg, Heidelberg, Germany.
Study Design: Retrospective Cohort Study.
Objectives: Flexibility radiographs such as traction or bending radiographs are essential in preoperative imaging to assess for curve flexibility and to estimate the amount of operative correction in order to determine the type and length of instrumentation in growth-accompanying scoliosis treatment. Both traction and bending radiographs are controversially discussed in the literature.
J Clin Med
January 2025
Jackie and Gene Autry Children's Orthopedic Center, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Postoperative ileus, the temporary cessation of gastrointestinal motility leading to accumulation of fluid and gas in the bowel, is a common complication following posterior spine fusion (PSF) in patients with neuromuscular scoliosis (NMS). Abdominal radiographs (KUBs) are often ordered to differentiate between ileus and mechanical obstruction but expose patients to radiation, add cost, and may lead to unnecessary work up. The aim of this study was to determine how often KUBs led to a change in treatment after PSF in patients with NMS.
View Article and Find Full Text PDFBrain Dev
January 2025
Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. Electronic address:
Background: Disease-modifying therapies can improve motor function in patients with spinal muscular atrophy (SMA), but efficacy varies between individuals. The aim was to evaluate the efficacy and safety of nusinersen treatment in children with SMA and to investigate prognostic factors.
Methods: Motor function, compound muscle action potential (CMAP), and other indicators were prospectively collected before and 14 months after nusinersen treatment.
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