Activation of latent papillomavirus genomes by chronic mechanical irritation.

J Gen Virol

Institute for Experimental Pathology, German Cancer Research Center, Heidelberg.

Published: November 1991

The skin of animals of a laboratory strain of Mastomys natalensis carrying endogenous, latent papillomavirus genomes was irritated by scratching with glasspaper. Hyperproliferation of the epidermis and amplification of viral DNA followed this treatment, and in approximately 27% of the animals virus-producing papillomas were induced.

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http://dx.doi.org/10.1099/0022-1317-72-11-2787DOI Listing

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