The aim of the present work was to investigate the use of thiolated chitosan in the development of polysaccharide-coated nanoparticles in order to confer specific functionality to the system. After chemical modification of commercial and hydrolysed chitosan (400,000 and 9400 g/mol respectively), thiolated chitosans were used to elaborate particles in the nano-range. They were characterized in terms of size and surface charge measurement. Both analysis showed nanoparticles of mean hydrodynamic diameter around 200 nm and positive zeta potential values, indicating the presence of the cationic polysaccharide at the nanoparticle surface. Moreover, the Ellman's reaction was used to demonstrate the presence of thiol groups at the particle surface. The observation of nanoparticles by scanning electronic microscopy (SEM) showed spherical nanoparticles for all formulations. This new system, combining both the advantages of thiolated polymers and colloidal particles can be proposed as an original drug carrier system for mucosal delivery of biotechnology products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2006.02.037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling.
J Am Soc Nephrol
January 2025
Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
Background: Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. This study aims to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure.
Methods: Skeletal muscle metabolism and AV fistula maturation were evaluated in mice with chronic kidney disease (CKD).
Chitosan-Functionalized Fluorescent Calcium Carbonate Nanoparticle Loaded with Methotrexate: Future Theranostics for Triple Negative Breast Cancer.
ACS Biomater Sci Eng
January 2025
Nano 2 Micro Material Design Lab, Department of Chemical Engineering and Technology, IIT (BHU), Varanasi 221005, India.
Herein, fluorescent calcium carbonate nanoclusters encapsulated with methotrexate (Mtx) and surface functionalized with chitosan (25 nm) (@Calmat) have been developed for the imaging and treatment of triple-negative breast cancer (TNBC). These biocompatible, pH-sensitive nanoparticles demonstrate significant potential for targeted therapy and diagnostic applications. The efficacy of nanoparticles (NPs) was evaluated in MDA-MB-231 TNBC cell lines.
View Article and Find Full Text PDFNanoparticles-Based Optical Chemosensors for Lead Acetate Sensing in Water: ZnO, ZnCeO, and ZnNdO.
J Fluoresc
January 2025
Materials Science Lab (1), Physics Department, Faculty of Science, Cairo University, Giza, Egypt.
This study reports the synthesis, characterization, and optical properties of ZnO, ZnCeO, and ZnNdO nanoparticles and their interactions with lead acetate solutions. X-ray diffraction (XRD) confirmed that the nanoparticles were synthesized in a single-phase hexagonal structure, with crystallite sizes of 12.48 nm, 50.
View Article and Find Full Text PDFIron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment.
Discov Nano
January 2025
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of nanotechnology, specifically nanoparticles, to tackle various challenges in cancer treatment.
View Article and Find Full Text PDFA comprehensive review of factors affecting growth and secondary metabolites in hydroponically grown medicinal plants.
Planta
January 2025
Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Optimizing environmental factors can significantly increase the growth and secondary metabolite synthesis of hydroponically grown medicinal plants. This approach can help increase the quality and quantity of pharmacologically important metabolites to enhance therapeutic needs. Medicinal plants are key therapeutic sources for treating various ailments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!