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Clinical Activity of Behcet's Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports.
Int Med Case Rep J
January 2025
Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Introduction: The Behçet's Disease Current Activity Form (BDCAF) is crucial for monitoring the progression and treatment efficacy of Behçet's Disease (BD), an autoimmune disorder that can be triggered or exacerbated by viral infections. Herpes simplex virus type 1 (HSV-1) has long been recognized as a potential trigger for BD, as it can induce systemic inflammation and exacerbate symptoms. In contrast, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently emerged and may also initiate or worsen BD symptoms.
View Article and Find Full Text PDFEffect of Epstein-Barr Virus infection on gene regulation in immune cells of patients with Immune-Mediated Diseases.
J Autoimmun
January 2025
Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:
It has been known that Epstein-Barr virus (EBV) can latently infect immune cells after the initial infection, and epidemiological studies have suggested its association with the onset of immune-mediated diseases (IMDs). However, the specific impact of EBV infection on IMDs pathology remains unclear. We quantified EBV load of B cell subsets (Naïve B cells, Unswitched memory B cells, Switched memory B cells, Double negative B cells, and Plasmablasts) in IMD patients as well as healthy control (HC) using bulk RNA sequencing data of 504 donors.
View Article and Find Full Text PDFMortality rate and standardized mortality ratio of childhood-onset type 1 diabetes according to incidentally detected non-acute-onset or acute-onset subtype, sex, and onset age: A cohort study.
Clin Pediatr Endocrinol
January 2025
Bibai City Hospital, Hokkaido, Japan.
IFN-α neutralizing antibodies distinguish LADA from early-onset type 1 diabetes.
J Clin Endocrinol Metab
January 2025
Department of Experimental Medicine, Sapienza University of Rome, Italy.
Article Synopsis
- Autoantibodies against IFN-α (AAb-IFN-α) may be linked to less aggressive autoimmune behaviors in latent autoimmune diabetes in adults (LADA) compared to early-onset type 1 diabetes (T1D).
- Researchers compared the presence of AAb-IFN-α in LADA (41 subjects) versus T1D (90 subjects) to determine its clinical significance.
- Results indicated a higher positivity for AAb-IFN-α isoforms in LADA patients, suggesting a unique autoimmune profile that could inform future therapeutic approaches in autoimmune diseases.
Inhibition of leukotrienes and their potential role in type 1 diabetes pathogenesis: implications for montelukast as a therapeutic agent: a case report.
Front Clin Diabetes Healthc
December 2024
Department of Medicine, NU Hospital Group, Trollhättan and Uddevalla, Sweden.
Introduction: Type 1 diabetes involves immune-mediated destruction of insulin-producing beta cells, with eosinophils potentially playing a significant role. Recent studies suggest that leukotriene inhibition might influence this process. This case report presents a novel observation of montelukast, a leukotriene receptor antagonist, reducing insulin requirements in a patient with Latent Autoimmune Diabetes in Adults (LADA).
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