AI Article Synopsis
- The klotho gene, linked to aging-related diseases, was studied to see if its G-395A polymorphism correlates with ischemic heart disease (IHD) risk in a Japanese population.
- A study involving 197 CAD patients, 77 VSA patients, and 331 healthy controls found a higher frequency of the A allele in CAD patients (29.9%) compared to controls (19.0%).
- Analysis showed the A allele as a significant independent predictor for CAD (odds ratio 1.76, p=0.03), but not for vasospastic angina (VSA), indicating that this genetic variant may specifically increase the risk for CAD.
Article Abstract
Background: The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes, including atherosclerosis. We tested the hypothesis that the G-395A polymorphism of the klotho gene is associated with increased risk for 2 types of ischemic heart disease in Japanese.
Methods: The study population consisted of 197 patients with coronary heart disease (CAD) who had >75% luminal diameter narrowing, 77 patients with vasospastic angina (VSA) without significant fixed coronary artery disease, and 331 healthy control subjects.
Results: The frequency of the A allele carriers of the klotho gene was significantly higher in the CAD group than in the control group (29.9% vs. 19.0%). The unadjusted odds ratio for CAD in the A allele carriers compared with the control group was 1.82 (p=0.004) and a traditional risk-adjusted logistic regression model revealed that the A allele was an independent predictor of CAD (odds ratio, 1.76; p=0.03). In contrast, the frequency of the A allele carriers was not significantly different in the VSA group (23.4%; adjusted odds ratio, 1.18.
Conclusions: The -395A polymorphism of the human klotho gene may be a genetic risk factor for IHD and not for VSA.
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| http://dx.doi.org/10.1016/j.cca.2006.02.021 | DOI Listing |
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