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Availability of assistive technologies (ATs) to children with disabilities in Bulawayo central district (BCD) in Zimbabwe.
Disabil Rehabil Assist Technol
January 2025
Zimbabwe Open University Bulawayo, Bulawayo, Zimbabwe.
Availability of assistive technologies (ATs) to children with disabilities is a critical human right enshrined in United Nations (UN) treaties and frameworks such as the United Nations Conventions on the Rights of Persons with Disabilities (UNCRPD), the United Nations Conventions on Rights of the Child (UNCRC), and United Nations 2030 Agenda for Sustainable Development. ATs optimize functionality, independence, and enhance educational experiences of children with disabilities. The study explored availability of ATs to children with disabilities in Bulawayo Central District (BCD) in Zimbabwe.
View Article and Find Full Text PDFIntegrated Analysis of Bulk RNA Sequencing, eQTL, GWAS, and Single-Cell RNA Sequencing Reveals Key Genes in Hepatocellular Carcinoma.
J Cell Mol Med
January 2025
Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Hepatocellular carcinoma (HCC) poses a continual therapeutic challenge owing to its elevated incidence and unfavourable prognosis, underscoring the critical need for the discovery of new molecular targets for detection and therapy. This work included the analysis of three publically accessible HCC datasets from TCGA and GEO. Instrumental variables (IVs) were derived via expression quantitative trait loci (eQTL) analysis, then followed by two-sample Mendelian randomisation (MR) analysis utilising publically available summary statistics.
View Article and Find Full Text PDFFar Cortical Locking Versus Standard Constructs for Locked Plate Fixation in the Treatment of Acute, Displaced Fractures of the Distal Femur: A Multicenter Randomized Trial.
J Bone Joint Surg Am
October 2024
Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Fixation of distal femoral fractures remains a challenge, and nonunions are common with standard constructs. Far cortical locking (FCL) constructs have been purported to lead to improved fracture-healing as compared with that achieved with traditional locking bridge plates. We sought to test this hypothesis in a comparative effectiveness clinical trial.
View Article and Find Full Text PDFDesign, Implementation and Environmental Impact of Cutoff Wall for Pollution Control in an Industrial Legacy Site.
Toxics
December 2024
Zhejiang Zone-King Environmental Sci & Tech Co., Ltd., Hangzhou 310064, China.
Heavy metal-organic pollutants compound pollution at industrial legacy sites and have caused damage to the ecological environment and human health during recent decades. In view of the difficulty and high cost of post-contamination remediation, it is worth studying, and practically applying, cutoff walls to reduce the spread of pollution in advance. In this study, field-scale studies were carried out at e-waste dismantling legacy sites in Taizhou, Zhejiang Province of China, through the process of site investigation, numerical simulation, and cutoff wall practical application.
View Article and Find Full Text PDFAflatoxin B1: Challenges and Strategies for the Intestinal Microbiota and Intestinal Health of Monogastric Animals.
Toxins (Basel)
January 2025
Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
The objective of this review is to investigate the impacts of aflatoxins, particularly aflatoxin B1 (AFB), on intestinal microbiota, intestinal health, and growth performance in monogastric animals, primarily chickens and pigs, as well as dietary interventions to mitigate these effects. Aflatoxin B1 contamination in feeds disrupts intestinal microbiota, induces immune responses and oxidative damage, increases antioxidant activity, and impairs jejunal cell viability, barrier function, and morphology in the small intestine. These changes compromise nutrient digestion and reduce growth performance in animals.
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