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| http://dx.doi.org/10.1073/pnas.35.5.244 | DOI Listing |
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A novel simulation-based analysis of a stochastic HIV model with the time delay using high order spectral collocation technique.
Sci Rep
April 2024
Department of Mathematics, College of Natural and Computational Sciences, Debre Berhan University, 445, Debre Berhan, Ethiopia.
The economic impact of Human Immunodeficiency Virus (HIV) goes beyond individual levels and it has a significant influence on communities and nations worldwide. Studying the transmission patterns in HIV dynamics is crucial for understanding the tracking behavior and informing policymakers about the possible control of this viral infection. Various approaches have been adopted to explore how the virus interacts with the immune system.
View Article and Find Full Text PDFStatic magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test.
Neurosci Lett
January 2023
Laboratory of Neuropsychobiology and Motor Behavior, Department of Health Sciences, Ribeirão Preto Medical School of the University of São Paulo (USP), AV. dos Bandeirantes, 3900 Ribeirão Preto, SP 14049-900, Brazil. Electronic address:
Studies have shown that psychotropic drugs change rat behavior in the elevated plus-maze test (EPM). This study investigated whether static magnetic fields could alter alprazolam-induced rat behavior in the EPM. 66 male Wistar rats (270-300 g weight) were assigned to one of the following groups: Sham Magnetic + Saline (SMS), North Pole + Saline (NPS), South Pole + Saline (SPS), Sham magnetic + alprazolam (SMA), NP + alprazolam (NPA), and SP + alprazolam (SPA).
View Article and Find Full Text PDFPredicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores.
Ann Intensive Care
December 2021
Département de Santé Publique, Centre de Pharmacoépidémiologie (Cephepi), INSER, Institut Pierre-Louis d'Epidémiologie et de Santé Publique, APHP, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.
Background: Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays.
Methods: The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID-ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19.
Restrictive Transfusion Strategy and Clinical Decision Support Practices for Reducing RBC Transfusion Overuse.
Am J Clin Pathol
October 2019
Gauss Surgical, Los Altos, CA.
Objectives: Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients.
Methods: Following the Centers for Disease Control and Prevention Laboratory Medicine Best Practice (LMBP) Systematic Review (A-6) method, studies were assessed for quality and evidence of effectiveness in reducing the percentage of patients transfused and/or units of blood transfused.
Results: Twenty-five studies on restrictive transfusion practice and seven studies on CPOE/CDS practice met LMBP inclusion criteria.
Importance: Muscle-related statin intolerance is reported by 5% to 20% of patients.
Objective: To identify patients with muscle symptoms confirmed by statin rechallenge and compare lipid-lowering efficacy for 2 nonstatin therapies, ezetimibe and evolocumab.
Design, Setting, And Participants: Two-stage randomized clinical trial including 511 adult patients with uncontrolled low-density lipoprotein cholesterol (LDL-C) levels and history of intolerance to 2 or more statins enrolled in 2013 and 2014 globally.
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