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| http://dx.doi.org/10.1073/pnas.5.4.126 | DOI Listing |
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Secondary Degeneration Impairs Myelin Ultrastructural Development in Adulthood following Adolescent Neurotrauma in the Rat Optic Nerve.
Int J Mol Sci
February 2023
Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6845, Australia.
Article Synopsis
- * A study on female rats showed that damaging the optic nerve during adolescence affects myelin structure, resulting in fewer axons with healthy myelin and altering myelin thickness in adulthood.
- * The findings suggest that injuries during adolescence can disrupt normal myelin development, leading to long-term consequences in brain function and structure.
Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.
Sci Rep
September 2022
Department of Neuroscience, Central Clinical School, Monash University, Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTBI) on cranial bone composition are unclear. We hypothesized that repeated mTBI (rmTBI) would change the microstructure of cranial bones, without gross skull fractures. To address this, young adult female Piebald Viral Glaxo rats received sham, 1×, 2× or 3× closed-head mTBIs delivered at 24 h intervals, using a weight-drop device custom-built for reproducible impact.
View Article and Find Full Text PDFTracing the retina to analyze the integrity and phagocytic capacity of the retinal pigment epithelium.
Sci Rep
April 2020
Departamento de Oftalmología, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain.
We have developed a new technique to study the integrity, morphology and functionality of the retinal neurons and the retinal pigment epithelium (RPE). Young and old control albino (Sprague-Dawley) and pigmented (Piebald Virol Glaxo) rats, and dystrophic albino (P23H-1) and pigmented (Royal College of Surgeons) rats received a single intravitreal injection of 3% Fluorogold (FG) and their retinas were analyzed from 5 minutes to 30 days later. Retinas were imaged in vivo with SD-OCT and ex vivo in flat-mounts and in cross-sections.
View Article and Find Full Text PDFPopulations of vertebrate species introduced onto islands regularly develop similar phenotypic changes, e.g., larger or smaller body size, shortened limbs, duller coats, as well as behavioural changes such as increased tameness and reduced flight-initiation distance.
View Article and Find Full Text PDFInflammation and blood-brain barrier breach remote from the primary injury following neurotrauma.
J Neuroinflammation
July 2018
Experimental and Regenerative Neurosciences, School of Biological Sciences, The University of Western Australia, Stirling Hwy, Perth, Western Australia, 6009, Australia.
Background: Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at and immediately adjacent to the injury site. However, few studies investigate how regions remote from the primary injury could also suffer from inflammation and secondary degeneration.
Methods: Adult female Piebald-Viral-Glaxo (PVG) rats underwent partial transection of the right optic nerve, with normal, age-matched, unoperated animals as controls.
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