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| http://dx.doi.org/10.1073/pnas.4.2.47 | DOI Listing |
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Education Research: Has Video Killed the Interview Star?: A Survey of Current Neurology Residents on In-Person vs Virtual Residency Interviews.
Neurol Educ
December 2024
From the Department of Neurology (W.A.D., A.M.S.), University of Virginia, Charlottesville; Department of Neurology (R.U.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Neurology (J.B.R.), Thomas Jefferson University, Philadelphia, PA; Department of Neurology (J.C.), University of Michigan Medical School, Ann Arbor; Department of Neurology (A.W.), University of Arizona College of Medicine - Phoenix; and Department of Public Health Sciences (J.T.P., A.M.S.), University of Virginia, Charlottesville.
Background And Objectives: The residency application process relies on interviews, which allow programs and applicants to assess one another. Historically, interviews were conducted in person at each program. With the advent of the coronavirus disease 2019 pandemic, residency interviews shifted to a virtual format.
View Article and Find Full Text PDFTamsulosin ameliorates bone loss by inhibiting the release of Cl through wedging into an allosteric site of TMEM16A.
Proc Natl Acad Sci U S A
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
TMEM16A, a key calcium-activated chloride channel, is crucial for many physiological and pathological processes such as cancer, hypertension, and osteoporosis, etc. However, the regulatory mechanism of TMEM16A is poorly understood, limiting the discovery of effective modulators. Here, we unveil an allosteric gating mechanism by presenting a high-resolution cryo-EM structure of TMEM16A in complex with a channel inhibitor that we identified, Tamsulosin, which is resolved at 2.
View Article and Find Full Text PDFEstimation of Spacecraft Angular Velocity Based on the Optical Flow of Star Images Using an Optimized Kalman Filter.
Biomimetics (Basel)
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College of Artificial Intelligence, China University of Petroleum, Beijing 100100, China.
Biomimetic vision is a promising method for efficient navigation and perception, showing great potential in modern navigation systems. Optical flow information, which comes from changes in an image on an organism's retina as it moves relative to objects, is crucial in this process. Similarly, the star sensor is a critical component to obtain the optical flow for attitude measurement using sequences of star images.
View Article and Find Full Text PDFAn inverted tetrahedron-mediated DNA walker for sulfadimethoxine detection.
Mikrochim Acta
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Shanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
An inverted DNA tetrahedron-mediated modular DNA walker was developed for the determination of sulfadimethoxine. The inverted DNA tetrahedron scaffold raises several advantages of recognition module including appropriate lateral space, multiple recognition domains, and cost-effectiveness. The proposed inverted DNA tetrahedron-based recognition module exhibited better binding affinity and kinetics toward target antibiotic than that of other DNA tetrahedron counterparts.
View Article and Find Full Text PDFThe Effect of Corticotomy-Assisted Orthodontic Therapy (CAOT) or Periodontally Accelerated Osteogenic Orthodontics (PAOO) on Bone Remodeling and the Health of Periodontium: A Systematic Review of Systematic Reviews.
J Clin Med
September 2024
Department of Dentofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
Orthodontic treatment involves moving teeth within the alveolar ridge. Bone remodeling is associated with the activity of osteoblasts and osteoclasts. Procedures such as corticotomy-assisted orthodontic therapy (CAOT) or periodontally accelerated osteogenic orthodontics (PAOO) are intended to reduce bone density and negative stress on the grip side and therefore limit bone resorption during orthodontic movement or add bone substitute material so that the tooth does not cross the vestibular plate.
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