AI Article Synopsis
- The study focuses on the biological characteristics of an intermediate form of Trypanosoma cruzi that occurs during the transformation from epimastigotes to trypomastigotes in a specific growth medium.
- Ultrastructural analysis reveals key features, such as the enlargement of the kinetoplast, indicating similarities between the intermediate and both trypomastigotes and epimastigotes.
- While sharing a similar surface charge with trypomastigotes, these intermediate forms lack resistance to immune responses and have limited ability to infect cultured fibroblast cells, primarily developing infections in macrophages.
Article Abstract
We describe some biological characteristics of the Trypanosoma cruzi intermediate form derived from the transformation of epimastigotes to trypomastigotes obtained from cultivation in modified liver infusion tryptose (LIT) medium. The ultrastructural analysis of the intermediate forms in this medium showed the enlargement of the kinetoplast located adjacent to the flagellate nucleus. Some biological characteristics of the intermediate form are similar to trypomastigotes and others to epimastigotes. Despite displaying a similar trypomastigote surface charge, the intermediate forms, like the epimastigotes, are not resistant to complement-mediated lysis. Moreover, the intermediate forms are unable to infect cultured fibroblasts cells but develop limited infections in macrophages.
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| http://dx.doi.org/10.1016/j.actatropica.2006.02.006 | DOI Listing |
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