Objective: To explore the effect of intralesional injection of low concentration 5-fluorouracil (5-FU) on inhibition of angiogenesis of keloid.
Methods: 35 patients with 51 keloids were treated with intralesional injection of 5-FU (2-5 mg/ml) biweekly. After 3-6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months.
Results: The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77%. For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14%. Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission.
Conclusion: Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.
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