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Catalyst for change: Psilocybin's antidepressant mechanisms-A systematic review.
J Psychopharmacol
January 2025
Division of Clinical Psychological Intervention, Freie Universität Berlin, Berlin, Germany.
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding of psilocybin's neurobiological and psychological antidepressant mechanisms is lacking.
Aims: Systematically review potential antidepressant neurobiological and psychological mechanisms of psilocybin.
Characteristics of Cognitive Event-Related Potential Components and N170 Source Analysis in Patients with Acute Cerebellar Infarction.
Cerebellum
January 2025
Department of Neurology, Kailuan General Hospital, No. 57 Xinhua East Road, Lubei District, Tangshan City, 063000, Hebei Province, China.
This study aims to evaluate cognitive impairments in patients with acute cerebellar infarction using event-related potentials (ERP) and electrophysiological source imaging (ESI). Thirty patients with acute cerebellar infarction and 32 healthy volunteers were selected. Cognitive potentials were recorded and measured using a visual Oddball paradigm.
View Article and Find Full Text PDFThe Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.
Entropy (Basel)
November 2024
Computational Neuroscience Group, UPF, 08005 Barcelona, Spain.
Major Depressive Disorder (MDD) is a complex, heterogeneous condition affecting millions worldwide. Computational neuropsychiatry offers potential breakthroughs through the mechanistic modeling of this disorder. Using the Kolmogorov theory (KT) of consciousness, we developed a foundational model where algorithmic agents interact with the world to maximize an Objective Function evaluating affective valence.
View Article and Find Full Text PDFPsychoanalytic object relations theory revised: Affect systems and the notion of drives.
Int J Psychoanal
October 2024
Department of Psychiatry, Weill Cornell Medical College, New York, USA.
This paper explores the concept of drives as basic motivational neurobiological structures determining the organization of psychic life. I express my agreement with Mark Solms' radical reformulation of the general principles organizing human behaviour at the neurobiological and psychodynamic levels, his combination of Friston's computational information theory and Panksepp's affect systems. I agree with him that the affect systems described by Panksepp constitute the primary drives and that the conflicts between affect systems are the origin of unconscious intrapsychic conflict.
View Article and Find Full Text PDFReevaluating ADHD and its First-Line Treatment: Insights from DSM-5-TR and Modern Approaches.
Clin Neuropsychiatry
October 2024
Ariel University, University of Cambridge.
Is Attention Deficit Hyperactivity Disorder (ADHD) a "brain disorder"? Should it be managed regularly with stimulant drugs? This article critically examines the evolving biomedical discourse surrounding these questions through a close inspection of the latest edition of the influential psychiatric manual - the DSM-5-TR - as well as additional authoritative sources (e.g., previous DSM editions, consensus statements, FDA communications).
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