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Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization.
Int J Mol Sci
January 2025
Louvain Institute of Molecular Science and Technology, Université catholique de Louvain, 5 (L7.07.10) Place Croix du Sud, 1348 Louvain-la-Neuve, Belgium.
genes play essential roles in patterning the anteroposterior axis of animal embryos and in the formation of various organs. In mammals, there are 39 genes organized into four clusters (HOXA-D) located on different chromosomes. In relationship with their orderly arrangement along the chromosomes, these genes show nested expression patterns which imply that embryonic territories co-express multiple genes along the main body axis.
View Article and Find Full Text PDFLoss of Hoxa5 function affects Hox gene expression in different biological contexts.
Sci Rep
December 2024
Centre de Recherche sur le Cancer de L'Université Laval, Centre de Recherche du CHU de Québec-Université Laval (Oncology), 1401, 18e Rue, Québec, QC, G1J 1Z4, Canada.
Hoxa5 plays numerous roles in development, but its downstream molecular effects are mostly unknown. We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and musculoskeletal tissues that present phenotypes in Hoxa5 mouse mutants. This global analysis revealed few common transcriptional changes, suggesting that HOXA5 acts mainly via the regulation of context-specific effectors.
View Article and Find Full Text PDFMolecular leveraging of HOX-embedded non-coding RNAs in the progression of acute myeloid leukemia.
Hum Cell
November 2024
Department of Medical Oncology, Dr. B.R.A. IRCH, All India Institute of Medical Sciences, Room No. 401, 4th Floor, New Delhi, India.
Acute myeloid leukemia (AML) is characterized by impaired differentiation of myeloid cells leading to hematopoietic failure. Despite advances, the molecular mechanisms driving AML remain incompletely understood, limiting the identification and targeting of critical vulnerabilities in leukemic cells. Homeobox (HOX) genes, encoding transcription factors essential for myeloid and lymphoid differentiation, are distributed across four clusters: HOXA (chromosome 7), HOXB (chromosome 17), HOXC (chromosome 12), and HOXD (chromosome 2).
View Article and Find Full Text PDFExpression Is an Independent Prognostic Biomarker in Esophageal Squamous Cell Carcinoma.
Genes (Basel)
November 2024
Laboratório de Toxicologia e Biologia Molecular, Departamento de Bioquímica, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20550-013, RJ, Brazil.
Article Synopsis
- Homeobox genes are important for organ development and differentiation, and in humans, they are divided into four clusters (HOXA, HOXB, HOXC, HOXD).
- This study focused on the role of these genes in esophageal squamous cell carcinoma (ESCC), finding that while mutations were rare, seven specific homeobox genes were significantly different in ESCC tissues compared to non-cancerous ones.
- The study revealed that these genes' dysregulation may affect cancer pathways and is linked to poor survival rates, suggesting their potential as prognostic biomarkers and targets for new therapies.
Analysis of DNA Methylation in Gliomas: Assessment of Preanalytical Variables.
Lab Invest
December 2024
Department of Neurosurgery, Houston Methodist Research Institute, Houston, Texas; Department of Neurological Surgery, University of Washington, Seattle, Washington; Department of Neurological Surgery, Weill Cornell Medicine, New York, New York.
Article Synopsis
- Precision oncology relies on biomarkers, with MGMT gene promoter methylation being a critical clinical biomarker for glioblastoma multiforme (GBM).
- Time-consuming preanalytical processes like biospecimen storage and intratumor methylation variability can affect data reproducibility, but research showed that standard processing techniques do not significantly alter MGMT methylation assessment.
- Despite consistent methods yielding reliable results, a significant portion of GBM specimens (26%-34%) displayed intratumor methylation heterogeneity, highlighting the necessity for multiple biopsies to accurately evaluate MGMT status.
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