A single particle confined in an asymmetric potential demonstrates an anticipated ratchet effect by drifting along the 'easy' ratchet direction when subjected to non-equilibrium fluctuations. This well-known effect can, however, be dramatically changed if the potential captures several interacting particles. Here we demonstrate that the inter-particle interactions in a chain of repelling particles captured by a ratchet potential can, in a controllable way, lead to multiple drift reversals, with the drift sign alternating from positive to negative as the number of particles per ratchet period changes from odd to even. To demonstrate experimentally the validity of this very general prediction, we performed transport measurements on a.c.-driven vortices trapped in a superconductor by an array of nanometre-scale asymmetric traps. We found that the direction of the vortex drift does undergo multiple reversals as the vortex density is increased, in excellent agreement with the model predictions. This drastic change in the drift behaviour between single- and multi-particle systems can shed some light on the different behaviour of ratchets and biomembranes in two drift regimes: diluted (single particles) and concentrated (interacting particles).
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http://dx.doi.org/10.1038/nature04595 | DOI Listing |
Prostate Int
September 2024
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
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Theranostics
January 2025
Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
: Tumor associated macrophages (TAMs) are critical components in regulating the immune statuses of the tumor microenvironments. Although TAM has been intensively studied, it is unclear how mitochondrial proteins such as AGK regulate the TAMs' function. : We investigated the AGK function in TAMs using macrophage-specific deficient mice with B16 and LLC syngeneic tumor models.
View Article and Find Full Text PDFTheranostics
January 2025
Department of Critical Care Medicine and Department of Anaesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China, 710032.
Record-breaking heatwaves caused by greenhouse effects lead to multiple hyperthermia disorders, the most serious of which is exertional heat stroke (EHS) with the mortality reaching 60 %. Repeat exercise with heat exposure, termed heat acclimation (HA), protects against EHS by fine-tuning feedback control of body temperature (Tb), the mechanism of which is opaque. This study aimed to explore the molecular and neural circuit mechanisms of the HA training against EHS.
View Article and Find Full Text PDFJ Gastrointest Oncol
December 2024
Department of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Hepatocellular carcinoma (HCC) patients with coronavirus disease 2019 (COVID-19) undergoing open surgery show increased adverse events (AEs) and mortality, while the safety of transarterial chemoembolization (TACE) in coinfected patients remains understudied, limiting available evidence. This study aims to investigate the safety of TACE in HCC patients coinfected with COVID-19, and to explore the potential risk factors affecting the occurrence of serious AEs (SAEs), thus providing evidence for clinical treatment strategies in such patients.
Methods: This retrospective study involved HCC patients who underwent TACE with or without COVID-19 infection at our institution from November 2022 to February 2023.
BMC Public Health
January 2025
Department of Health Management of Public Health, College of Public Health, Zhengzhou University, 100 Kexue Road, Gaoxin district, Zhengzhou, Henan, 450001, China.
Background: Although China has implemented multiple policies to encourage childbirth, the results have been underwhelming. Migrant workers account for a considerable proportion of China's population, most of whom are of childbearing age. However, few articles focus on their fertility intentions.
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