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Emerging significance of butyrylcholinesterase.
World J Exp Med
March 2024
Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, Andhra Pradesh, India.
Article Synopsis
- Butyrylcholinesterase (BChE) is an important enzyme in the human body that detoxifies certain chemicals like succinylcholine, commonly used in anesthesia.
- Some populations have variant forms of BChE that can lead to prolonged apnea after succinylcholine use, highlighting its role in drug metabolism and potential health risks.
- Research on BChE may reveal its implications for various health conditions, including insulin resistance, diabetes, and cognitive disorders, and could help determine its usefulness as a biomarker for diseases like Alzheimer's.
Neuromuscular Blockade and Reversal Practice Variability in the Outpatient Setting: Insights From US Utilization Patterns.
Anesth Analg
December 2021
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Background: Neuromuscular blockade (NMB) is a critical part of many surgical procedures. Data on practice patterns of NMB agents (NMBAs) and NMB reversal in recent years in the US ambulatory surgical care setting are limited.
Methods: This retrospective analysis of US adult outpatients was conducted using the Premier Healthcare Database.
Laryngotracheal Reconstruction in the Pediatric Burn Patient: Surgical Techniques and Decision Making.
J Burn Care Res
July 2020
Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston.
The management of laryngotracheal stenosis (LTS) in the pediatric burn patient is complex and requires a multidisciplinary approach. The mainstay of treatment for LTS is laryngotracheal reconstruction (LTR), however, limited reports of burn-specific LTR techniques exist. Here, we provide insight into the initial airway evaluation, surgical decision making, anesthetic challenges, and incision modifications based on our experience in treating patients with this pathology.
View Article and Find Full Text PDFSugammadex as a reversal agent for neuromuscular block: an evidence-based review.
Core Evid
June 2014
Klinik für Anaesthesiologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany ; Department of Anesthesia, Massachusetts General Hospital, Boston, MA, USA.
Sugammadex is the first clinical representative of a new class of drugs called selective relaxant binding agents. It has revolutionized the way anesthesiologists think about drug reversal. Sugammadex selectively binds rocuronium or vecuronium, thereby reversing their neuromuscular blocking action.
View Article and Find Full Text PDFUsing vertebral movement and intact paraspinal muscles to determine the distribution of intrafusal fiber innervation of muscle spindle afferents in the anesthetized cat.
Exp Brain Res
March 2013
Palmer Center for Chiropractic Research, 741 Brady Street, Davenport, IA 52803, USA.
Increasing our knowledge regarding intrafusal fiber distribution and physiology of paraspinal proprioceptors may provide key insights regarding proprioceptive deficits in trunk control associated with low back pain and lead to more effective clinical intervention. The use of vertebral movement as a means to reliably stretch paraspinal muscles would greatly facilitate physiological study of paraspinal muscle proprioceptors where muscle tendon isolation is either very difficult or impossible. The effects of succinylcholine (SCh) on 194 muscle spindle afferents from lumbar longissimus or multifidus muscles in response to computer-controlled, ramp-and-hold movements of the L(6) vertebra were investigated in anesthetized cats.
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