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Role of Oxidative Stress and Inflammation in Postoperative Complications and Quality of Life After Laryngeal Cancer Surgery.
Cells
November 2024
Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, P.O. Box 38, 11129 Belgrade, Serbia.
(1) Background: Laryngeal surgery due to carcinoma leads to significant tissue disruption, cellular injury, and inflammation. This leads to increased levels of reactive oxygen species (ROS), causing oxidative damage that can influence quality of life (QOL) and recovery and complicate the postoperative course. The aim of this study was to compare how postoperative quality of life and surgical complication occurrence interacted with the biomarker levels of oxidative stress (malondialdehyde, MDA; superoxide dismutase, SOD; glutathione peroxidase 1, GPX1; and catalase, CAT) and inflammation (interleukin 1, IL-1; interleukin 6, IL-6; C-reactive protein, CRP) in patients treated with conservative and radical laryngeal surgery.
View Article and Find Full Text PDFThe history of lobotomy as a neuropsychiatric intervention in Brazil - a case report of a geriatric patient.
Neurocase
December 2024
Psiquiatria Geriátrica, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Lobotomy was a widespread neurosurgical procedure in the first half of the 20th century. It was used as a treatment for various mental disorders. The development of psychosurgeries in Brazil, their indications, effects, consequences, advancements, as well as the social context of the population subjected to it are revised herein.
View Article and Find Full Text PDFMechanical thrombectomy failure in anterior and posterior circulation stroke: current results from a high-volume comprehensive center.
Neurol Sci
November 2024
Department of Neuroradiology, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, Lübeck, 23538, Germany.
Background: Mechanical thrombectomy (MT) is an established therapy for acute ischemic stroke (AIS), but recanalization is not always achieved. Common reasons are inadequate removal at the thrombus site and difficulties with the access route. In order to identify risk factors for MT failure we conducted a retrospective study on a high-volume comprehensive stroke center.
View Article and Find Full Text PDFShort-course hypofractionated proton beam therapy, incorporating F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm phase 2 trial.
Lancet Oncol
December 2024
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Background: Older patients (aged ≥65 years) with glioblastoma have a worse prognosis than younger patients and a median overall survival of 6-9 months. 3,4-Dihydroxy-6-[F]fluoro-L-phenylalanine (F-DOPA) PET sensitively and specifically identifies metabolically active glioblastoma for preferential targeting. Proton beam therapy potentially improves quality of life (QOL) by sparing more healthy brain tissue than photon radiotherapy.
View Article and Find Full Text PDFStress and Quality of Life of Parents of Children With POLR3-Related Leukodystrophy: A Cross-Sectional Pilot Study.
J Child Neurol
January 2025
Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
RNA polymerase III (POLR3)-related leukodystrophy is a rare, neurodegenerative disorder characterized by hypomyelination, hypodontia, and hypogonadotropic hypogonadism. Despite the challenges of caring for a child with POLR3-related leukodystrophy, few studies have examined parents' disease burden. We sought to investigate quality of life and stress levels amongst parents of children with POLR3-related leukodystrophy.
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