AI Article Synopsis
- A 46-year-old woman with intrahepatic biliary duct hypoplasia developed hepatocellular carcinoma (HCC) after years without significant liver disease.
- A sudden increase in serum bilirubin levels led to the discovery of a large tumor during an orthotopic liver transplantation.
- This case highlights that HCC can still develop in patients with long-standing conditions like biliary duct hypoplasia, even when they have not experienced exacerbated liver issues.
Article Abstract
We describe the development of hepatocellular carcinoma (HCC) in a 46-yr-old woman with intrahepatic biliary duct hypoplasia. Her underlying liver disease was quiescent for many years until a dramatic rise in serum bilirubin was seen. Orthotopic liver transplantation was performed, and a large tumor was found during surgery. A bile-producing HCC was identified, infiltrating about 50% of an otherwise noncirrhotic liver which had a paucity of intrahepatic ducts. The findings of HCC in this long-term survivor of intrahepatic biliary duct hypoplasia indicates HCC may occur in patients with long-standing disease.
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