Disseminated transmissible venereal tumor in a dog.

J Vet Diagn Invest

Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Korea.

Published: January 2006

AI Article Synopsis

  • Transmissible venereal tumor (TVT) is a rare, transplantable tumor in dogs that shows no preference for breed or sex and has a low rate of spreading to other areas.
  • A case of a 2-year-old female Mastiff with multiple rapidly growing subcutaneous masses and metastases in various organs led to euthanasia due to a poor prognosis.
  • The diagnosis of TVT was confirmed through cytology, histology, immunohistochemical staining, and analysis of genetic elements, highlighting the use of polymerase chain reaction for differentiating canine round cell tumors.

Article Abstract

Transmissible venereal tumor (TVT) is a well-documented transplantable tumor in dogs, with no breed or sex predilection and a low metastatic rate. In this report, a 2-year-old intact female Mastiff that had numerous, rapidly growing masses throughout the subcutis mainly at the dorsal body plane, the caudal half of the ventral abdomen, and around the vulva was euthanized due to poor prognosis. Neoplastic nodules similar to those seen in the subcutis were also noted in the lung, anterior mediastinum, liver, spleen, kidney, and superficial and deep lymph nodes in both abdominal and thoracic cavities. The neoplastic nodules from the subcutis as well as metastatic foci revealed similar cytologic and histologic features, which were consistent with canine TVT. By immunohistochemical staining, the neoplastic cells were positive for lysozyme and vimentin but were negative for cytokeratin, desmin, CD3, and CD79a. The diagnosis of the TVT was further supported by the identification and analysis of long interspersed nuclear elements (LINE) from paraffin-embedded tumor tissue. This case is a rare example of TVT with multiorgan metastasis. In this case, the polymerase chain reaction technique was useful in differential diagnosis of canine round cell tumors because this technique can be applied in retrospective as well as future study.

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Source
http://dx.doi.org/10.1177/104063870601800123DOI Listing

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