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Pseudomyxoma retroperitonei secondary to appendiceal mucinous adenocarcinoma disguised as psoas abscess - A case report.
Int J Surg Case Rep
January 2025
Department of Surgery, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan. Electronic address:
Article Synopsis
- Appendiceal cancers, particularly mucinous cystadenocarcinoma, are rare and can cause serious complications like pseudomyxoma peritonei, leading to abdominal fluid accumulation called "jelly belly."
- A case of a young man with a persistent psoas abscess revealed mucinous adenocarcinoma with pseudomyxoma retroperitonei, emphasizing the need to consider malignancy in atypical abscesses.
- Early and accurate diagnosis is critical because these types of tumors can be misdiagnosed as common issues like abscesses, highlighting the importance of imaging and colonoscopy in identifying them.
Prognostic value of carcinoembryonic antigen in colorectal adenocarcinoma: expanding hypotheses into clinical practice.
Clin Exp Med
January 2025
Liver & Peritonectomy Unit, Department of Surgery, St George Hospital, Pitney Building, Short Street, Kogarah, NSW, 2217, Australia.
Purpose: This study seeks to resolve a fundamental question in oncology: Why do appendiceal and colorectal adenocarcinomas exhibit distinct liver metastasis rates? Building on our prior hypothesis published in the British Journal of Surgery, our institution has investigated potential DNA mutations within the carcinoembryonic antigen-related cell adhesion molecule (CEACAM5) gene's Pro-Glu-Leu-Pro-Lys (PELPK) motif to evaluate its role as a biomarker for liver metastasis risk.
Methods: Partnering with the Australian Genome Research Facility, the PELPK motif of CEACAM5 was analysed in colorectal and appendiceal adenocarcinomas to detect DNA mutations associated with liver metastasis. Additionally, our institution performed the COPPER trial to assess carcinoembryonic antigen (CEA) levels in portal versus peripheral blood in patients with appendiceal adenocarcinoma and a systematic review and meta-analysis of 136 studies on CEA's prognostic significance among patients with colorectal and appendiceal adenocarcinoma.
Should an Interval Appendicectomy Be Performed by a Minimally Invasive Gynaecologist?
Int J Womens Health
December 2024
Sydney Women's Endosurgery Centre (SWEC), St George Hospital, Sydney, NSW, Australia.
Objective: We aimed to explore the abnormal pathology findings in appendix specimens removed based on intraoperative abnormal appearance during elective surgery for benign gynaecological conditions by a minimally invasive gynaecologist, as well as the associated complication rate.
Materials And Methods: This retrospective cohort study was conducted in a tertiary referral surgical centre for benign gynaecological conditions between the years 2004-2023. It included patients who underwent appendicectomy by a trained minimally invasive gynaecologist based on observations during surgery for benign gynaecological conditions.
Mutations of the CEACAM5 Gene PELPK Motif in Patients With Appendiceal or Colorectal Adenocarcinoma.
In Vivo
December 2024
Liver & Peritonectomy Unit, Department of Surgery, St George Hospital, Kogarah, NSW, Australia.
Background/aim: The study examines whether DNA level mutations in the carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene Pro-Glu-Leu-Pro-Lys (PELPK) motif differ between patients with appendiceal or colorectal adenocarcinoma. Significant differences between these two groups in correlation with development of metachronous liver metastases could help in the development of targeted therapies and preventative treatment approaches.
Patients And Methods: This retrospective comparative trial analysed 18 patients, 9 with appendiceal adenocarcinoma and 9 with colorectal adenocarcinoma.
Development of a Prognostic Model for Stage IV Colorectal Cancer Using Metastatic Patterns.
Anticancer Res
January 2025
Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Koriyama, Japan.
Background/aim: Metastatic patterns are the most convenient and common prediction models for the prognosis of patients with stage IV colorectal cancer. However, current prediction models do not include the severity of metastases in organs and exclude certain types of metastatic patterns. The aim of this study was to develop a prediction model that included several metastatic organs as well as the severity of liver and lung metastases, based on the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3 English Edition.
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