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Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study.
Sci Rep
December 2024
Department of Pharmacognosy, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Despite significant advancements with combination anti-retroviral agents, eradicating human immunodeficiency virus (HIV) remains a challenge due to adverse effects, adherence issues, and emerging viral resistance to existing therapies. This underscores the urgent need for safer, more effective drugs to combat resistant strains and advance acquired immunodeficiency syndrome (AIDS) therapeutics. Eight triterpene esters (1-8) were identified from Uncaria rhynchophylla hooks.
View Article and Find Full Text PDFOptimal exercise dose-response improves health-related quality of life in cancer survivors: a systematic review and Bayesian network meta-analysis of RCTs.
Front Oncol
December 2024
The School of Electrical & Automation Engineering, East China Jiaotong University, Nanchang, China.
Objective: Cancer survivors often face significant health-related quality of life (HRQoL) challenges. Although exercise has been proven to improve HRQoL in cancer survivors, the optimal dose and intensity of exercise for this population has not been fully determined. Adherence to exercise may vary based on exercise intensity, affecting results.
View Article and Find Full Text PDFCoverage of Recommended Vaccination Among Adult Patients With Asthma in Riyadh, Saudi Arabia.
Cureus
December 2024
Department of Family and Community Medicine, Riyadh Second Health Cluster, Riyadh, SAU.
Introduction Asthma prevalence among Saudi adults aged 20-44 years in Riyadh is high, with 11.3% reporting physician-diagnosed asthma, exceeding rates in most countries using similar methods. In Aseer province, one out of five adults is estimated to have asthma.
View Article and Find Full Text PDFApproach to death and dying patients and its relation with death anxiety among medical interns: a multicenter cross-sectional study.
BMC Psychol
December 2024
Faculty of Medicine, Albalqaa Applied University, Al-Salt, Jordan.
Background: Dealing with death and dying patients is one of the most challenging aspects of medical practice. The purpose of this study was to assess the attitude of medical interns toward death and dying patients as well as their level of death anxiety.
Methods: This cross-sectional study was conducted on medical interns across three countries-Egypt, Jordan, and Palestine-using an online survey created with Google Forms.
An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation study.
BMC Musculoskelet Disord
December 2024
Department of Orthopedics, Hainan Hospital of PLA General Hospital, Hainan, China.
Background: Prolonged dependence on mechanical ventilation is a common occurrence in clinical ICU patients and presents significant challenges for patient care and resource allocation. Predicting prolonged dependence on mechanical ventilation is crucial for improving patient outcomes, preventing ventilator-associated complications, and guiding targeted clinical interventions. However, specific tools for predicting prolonged mechanical ventilation among ICU patients, particularly those with critical orthopaedic trauma, are currently lacking.
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