AI Article Synopsis
- The study aimed to analyze the T(1rho) dispersion profile in various rat tissues (liver, brain, spleen, kidney, heart, and skeletal muscle) under low B(0) field conditions.
- The results indicated that liver and muscle had the highest R(1rho) relaxation rates, while the spleen, kidney, and brain exhibited similar values.
- The findings suggest that T(1rho) imaging could enhance MR imaging by combining the benefits of low-field contrast and high signal-to-noise ratios typical of high-field imaging.
Article Abstract
The purpose of this study was to show the T(1rho) dispersion profile in various rat tissues (liver, brain, spleen, kidney, heart and skeletal muscle) at low (0.1 T) B(0) field at very low locking field B1, starting from 10 microT. The T(1rho) dispersion profile showed a quite similar pattern in all tissues. The highest R(1rho) relaxation rates were seen in the liver and muscle followed by the heart, whereas the values for spleen, kidney and brain were rather similar. The greatest difference between R2 relaxation rate and R(1rho) relaxation rate at B1=10 microT was seen in the liver and muscle. The steepest slope for a dispersion curve was seen in the muscle. The value of T(1rho) approximately approached the value of T2 when the locking field B1 approached 0. Except for the liver, the calculated apparent relaxation rate R2' was slightly larger than the calculated one. The potential value of T(1rho) imaging is to combine high R1 contrast of low-field imaging with the high signal-to-noise ratio (SNR) of high static field imaging. T(1rho) relaxation and dispersion data presented in the current study help to optimize the rotating-frame MR imaging.
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| http://dx.doi.org/10.1016/j.mri.2005.04.011 | DOI Listing |
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Article Synopsis
- The study aims to evaluate how effective different MRI techniques (T1ρ dispersion and Gd-EOB-DTPA-enhanced T1 mapping) are in detecting early liver fibrosis and non-alcoholic steatohepatitis in rabbits with a fatty liver diet.
- Results show significant differences in various MRI metrics when comparing rabbits with normal livers to those with varying degrees of liver fibrosis and NASH, indicating these imaging techniques can help in early diagnosis.
- T1ρ dispersion proved to be the most effective measure for identifying early liver fibrosis, while △T1 and HBP T1 showed superior performance for diagnosing NASH compared to T1ρ variations.
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