AI Article Synopsis
- Recent studies have identified highly conserved nongenic sequences (CNGs) and ultraconserved elements (UCEs) in both human and mouse genomes, which are notable for their lack of known function and extreme conservation.
- An alignment-free approach is necessary for analyzing these sequences due to the absence of detectable homology between similar CNGs and UCEs across the two species.
- The research utilizes Fourier techniques to examine the structural properties of these sequences based on a database of 32,896 unique DNA octamers, aiming to uncover potential functions through structural correlations.
Article Abstract
Recent comparative studies of the human and mouse genomes have revealed sets of conserved nongenic sequences (CNGs) and sets of ultraconserved elements (UCEs). Both sets of sequences, which exhibit extremely high levels of conservation, extend over hundreds of bases and have no known function. Since there is no detectable sequence homology between paralogous CNGs or UCEs in either of the species, an alignment-free technique is needed for their analysis. We have previously compiled a database of the structural properties of all 32,896 unique DNA octamers, including information on stability, the minimum energy conformation, and flexibility. We have used Fourier techniques to analyze the UCEs and CNGs in terms of their octamer structural properties, to reveal structural correlations which may indicate possible functions for some of these sequences.
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| http://dx.doi.org/10.1021/ci050384i | DOI Listing |
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