60 healthy volunteers ranging in age from 15 to 75 years participated in the study. Tibial nerve was stimulated unilaterally or bilaterally at the ankle and SEPs were recorded along the somatosensory pathway. Determination and readability of the potentials were evaluated according to the stimulating and recording method. After unilateral stimulation, the following derivation system was regarded as most useful in routine testing: L4 - Ic (iliac crest), Th12 - Ic, Cz' - Fz, Fz - Shoulder (and, if possible C7 - Fz). When more detailed spinal cord diagnosis is indicated, bilateral stimulation and recording in montage: Th6 - Shoulder, C7 - Shoulder, C7 - Fz, Fz - Shoulder may be helpful. In the study normal values of parameters of the potentials from certain derivations were presented: latencies, amplitudes, peripheral conduction velocities and central conduction times were taken into account. According to our own results (correlative analysis of SEP parameters) and the results of other authors, interpretation of the potentials on various levels of the ascending somatosensory pathway was discussed.
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Unlabelled: Layer 6 corticothalamic (L6CT) neurons project to both cortex and thalamus, inducing multiple effects including the modulation of cortical and thalamic firing, and the emergence of high gamma oscillations in the cortical local field potential (LFP). We hypothesize that the high gamma oscillations driven by L6CT neuron activation are shaped by the dynamic engagement of intracortical and cortico-thalamo-cortical circuits. To test this, we optogenetically activated L6CT neurons in NTSR1-cre mice expressing channelrhodopsin-2 in L6CT neurons.
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Division of Spine Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Ave, Guangzhou, 510515, People's Republic of China.
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Department of Psychology, Vanderbilt University, Nashville, TN 37240.
Lesions of the dorsal columns of the spinal cord in adult macaque monkeys lead to the loss of hand inputs and large-scale expansion of the face inputs in the hand region of the somatosensory cortex. Inputs from alternate spinal pathways do not reactivate the deafferented regions of area 3b. Here, we determined how transections of the dorsal columns done within a few days after birth affect the developing somatosensory cortex.
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School of Life Science and Technology, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China.
The selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The class IV dendritic arborization (C4da) sensory neurons of Drosophila remodel the dendritic branches during metamorphosis. Glial cells in the central nervous system (CNS), are required for programmed axonal pruning of mushroom body (MB) γ neurons during metamorphosis in Drosophila.
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January 2025
Department of Neurosurgery and Neurotechnology, Eberhard Karls University, Tübingen, Germany.
Objective: Epilepsy is considered as a network disorder of interacting brain regions. The propagation of local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines the semiology of seizures. However, in highly interconnected brain regions such as the insula, the association between the SOZ and semiology is blurred necessitating invasive stereoelectroencephalography (SEEG).
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