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Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera. | LitMetric
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Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera.

Wei-Lie Xiao Jian-Xin Pu Ying Chang Xiao-Li Li Sheng-Xiong Huang Liu-Meng Yang Li-Mei Li Yang Lu Yong-Tang Zheng Rong-Tao Li Qi-Tai Zheng Han-Dong Sun

Org Lett

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.

Published: March 2006

[structure: see text] Two novel nortriterpenoid compounds, sphenadilactones A (1) and B (2), have been isolated from the leaves and stems of Schisandrasphenanthera. The structural elucidation of 1 and 2 was accomplished by extensive NMR analysis. The relative stereochemistry of 1 was established by single-crystal X-ray crystallography. Both compounds were tested for their cytotoxicities against K562, A549, and HT-29, and compound 1 was further tested for its anti-HIV-1 activity.

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http://dx.doi.org/10.1021/ol060324dDOI Listing

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