Methods have been developed for the pilot-scale production of group A and group C meningococcal polysaccharide immunogens based on the meningococcal strains, the medium, and the basic processing procedures used by Gotschlich et al. Physical and chemical assays on the final products obtained on a pilot-scale level indicate that these purified polysaccharides are entirely comparable to the Gotschlich preparations which proved to be immunogenic in man.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC416062 | PMC |
| http://dx.doi.org/10.1128/iai.2.5.640-643.1970 | DOI Listing |
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