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Trisaccharide mimetics of the aminoglycoside antibiotic neomycin. | LitMetric

Trisaccharide mimetics of the aminoglycoside antibiotic neomycin.

Org Biomol Chem

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

Published: April 2006

AI Article Synopsis

Article Abstract

A highly convergent approach for the chemical synthesis of eight structurally related trisaccharides that contain 3 to 5 amino groups has been described. Fourier-transformation ion cyclotron resonance mass spectrometry (FT-ICR MS) has been employed to determine the dissociation constants (Kd) for the binding of the trisaccharides to a prototypical fragment of 16S ribosomal RNA. A compound that contained a 4,6-dideoxy-4-amino-beta-D-glucopyranoside moiety at C-3 displayed binding in the low micromolar range. It was found that small structural changes of the saccharides resulted in large differences in affinity. The described structure-activity relationship is expected to be valuable for the development of novel antibiotics that target rRNA.

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Source
http://dx.doi.org/10.1039/b517725aDOI Listing

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