AI Article Synopsis
- The case involves a 65-year-old woman who developed chronic graft-versus-host disease (GVHD) with severe skin sclerosis after undergoing autologous peripheral blood stem cell transplantation (APBSCT) for breast cancer.
- Four years post-transplant, she experienced significant sclerotic changes in her skin, confirmed by biopsy, but showed no anti-nucleolar DNA in her serum, leading to a diagnosis of chronic GVHD.
- Despite treatment with oral prednisolone, her skin condition worsened, she had a recurrence of breast cancer, and ultimately passed away from complications related to pericarditis.
Article Abstract
We report a 65-year-old woman with chronic graft-versus-host disease (GVHD) who developed severely sclerotic skin on the fingers, hand and trunk following autologous peripheral blood stem cell transplantation (APBSCT). The patient had suffered from breast cancer and been treated with surgery and chemotherapy. She showed pancytopenia and was treated with APBCST. Four years after APBSCT, she developed the severe sclerotic changes on the fingers, hands, extremities and trunk. The skin biopsy showed a flattened epidermis and a proliferation of collagen bundles in the dermis. No anti-nucleolar DNA titers were detected in the serum. She was diagnosed with chronic GVHD. Despite treatment with oral prednisolone, the skin sclerotic change developed and the breast cancer recurred. She died due to pericarditis. This is a rare case of sclerodermatous GVHD following APBSCT. The serum interleukin (IL)-12 levels were examined during the treatment.
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| http://dx.doi.org/10.1111/j.1346-8138.2006.00029.x | DOI Listing |
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