AI Article Synopsis
- Uranium miners face a well-documented heightened risk of lung cancer, but their risk for other cancers, specifically leukemia, was the focus of this study.
- A case-control study involving 377 leukemia cases and 980 controls examined whether exposure to radon and radiation impacts leukemia risk among former miners in East Germany.
- The findings indicated that while there was no confirmed dose-response link with radon progeny, miners exposed to higher combined levels of gamma-radiation and long-lived radionuclides showed an elevated leukemia risk, particularly for those with lengthy mining careers.
Article Abstract
Background: It is well known that uranium miners are at an increased risk of lung cancer. Whether they also have an increased risk for other cancer sites remains under discussion. The aim of this study was to examine the leukemia risk among miners.
Methods: An individually matched case-control study of former uranium miners in East Germany was conducted with 377 cases and 980 controls.
Results: Using conditional logistic regression models, a dose-response relationship between leukemia risk and radon progeny could not be confirmed. Yet, a significantly elevated risk is seen in the category > or = 400 mSv when combining gamma-radiation and long-lived radionuclides.
Conclusions: The results suggest that an elevated risk for leukemia is restricted to employees with a very long occupational career in underground uranium mining or uranium processing. Moreover, the study does not support the hypothesis of an association between exposure to short-lived radon progeny and leukemia risk.
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| http://dx.doi.org/10.1002/ajim.20289 | DOI Listing |
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