Prophylaxis of cerebrovascular events in dementia patients receiving risperidone.

Consult Pharm

Cornerstone Pharmacy Services, Indianapolis, Indiana, USA.

Published: September 2005

Objective: To determine if differences exist in prescribing for cerebrovascular adverse event (CAE) prophylaxis between residents receiving risperidone therapy and those with no antipsychotic therapy.

Design: Retrospective, multicentered, cross-sectional study.

Setting: Ten long-term care facilities.

Participants: A total of 200 residents residing in skilled nursing facilities. The study group (n = 95) included residents with a risk factor for a CAE receiving risperidone. The control group (n = 105) consisted of residents with a risk factor for a CAE and not receiving antipsychotic therapy.

Measurements: Data collected included patient age, gender, risk factor for CAE, and CAE prophylaxis. Statistics were performed using Chi-squared tests.

Results: Fifty-six percent of the study group was not on an agent for CAE prophylaxis, compared with 36% of the control group.

Conclusion: This study demonstrated with statistical significance that CAE prophylaxis was less likely in the risperidone group. We are implementing a pharmacist-driven initiative to add antiplatelet therapies in all patients who have at least one risk factor for CAE.

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http://dx.doi.org/10.4140/tcp.n.2005.747DOI Listing

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