AI Article Synopsis
- The study investigates the protective effects of total alkaloids (TA) from Coptis chinensis against alcohol-induced gastric lesions in rats, focusing on various gastric damage indicators.
- TA demonstrated a dose-dependent reduction in gastric damage caused by ethanol, proving more effective than cimitidine and berberine at specified doses, while also affecting gastric acid secretion.
- The findings suggest that TA helps protect the gastric mucosa by inhibiting acid secretion and mitigating oxidative stress markers, emphasizing its potential as a therapeutic agent for gastric damage.
Article Abstract
Objective: To study the effects of total alkaloids(TA) from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats and the possible mechanisms.
Method: The experimental gastric damges were established by intragastric(ig) absolute ethanol, and possible protective effects of TA given orally previously were evaluated by following parameters: gastric damage indexes, gastric juice volume, acidity, and mucus quantity. The contents of NO, MDA, *OH, and SOD activity were also measured in gastric mucosa.
Result: TA showed significantly inhibitive effects on gastric damages induced by ig ethanol in a dose dependent manner. The effects of TA (120 mg x kg(-1)) were stronger than that of both cimitidine(70 mg x kg(-1)) and berberine(100 mg x kg(-1)), the quantity of later was equal to TA as calculated with berberine. TA significantly suppressed secretion of gastric acid caused by ethanol without clear influences on gastric juice volume and mucus secretion. TA obviously blunted ethanol-induced elevation of MDA and *OH, as well as decrease of NO level and SOD activity from gastric mucosa.
Conclusion: It is suggested that the TA is a potent protective agent against ethanol-induced gastric damages. The mechanism of actions may be related with inhibiting the secretion of gastric acid and blunting the increase of MDA and *OH, as well as the decrease of NO level and SOD activity from gastric mucus.
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