Ten young males with rhinopharyngeal angiofibroma (RAG) were studied. Except for one case of IIIb stage the others were all either I or IIIa. They all underwent surgery at the E.N.T. Clinic in Ferrara employing the transpharyngeal suprahyoid approach (TSA) originally described by Bocca. For the one case in the most advanced stage (IIIb), besides the TSA a paralateronasal approach and a complementary RT were also planned. In this series of cases, one recurrence due to a peritubaric residue was treated 8 months later through a transpalatal approach. The follow-up, with NED findings, varied from a maximum of 12 to minimum of 2 years (average 6.4 years), except for the last subject which underwent surgery in 1991. Three minor post-operative complications due to TSA were encountered, while 1 complication was attributed to the transpalatal approach used for the recurrence described. All cases healed completely. The data on the TSA from the international and national literature is reviewed underlining that the negative elements reported have, in the authors' opinion, been overcome by: perfecting the method for RAG exeresis and the method of the tracheotomy; making technological improvements: pre-operatory embolization, microsurgery applied to TSA in order to check any lateral branches and to the transnasal approach in order to check any residue in the choanal area.
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Epilepsy Res
January 2025
Division of Pediatric Neurology, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 8th Floor Faculty Pavilion, 4401 Penn Ave., Pittsburgh, PA 15224, United States. Electronic address:
Purpose: Responsive neurostimulation of the centromedian nucleus of the thalamus (CM RNS) is being investigated for treatment of drug-resistant generalized epilepsy with promising results. The aim of this study is to report outcomes of seven patients with pediatric-onset drug-resistant generalized epilepsy, including both genetic generalized epilepsy (GGE) and Lennox-Gastaut syndrome (LGS), who underwent treatment with bilateral CM RNS.
Methods: A retrospective chart review was performed for patients with drug-resistant generalized epilepsy who underwent treatment with bilateral CM RNS at Children's Hospital of Pittsburgh from 2020 to 2022.
Knee
January 2025
Department of Orthopaedics, Juntendo University, Faculty of Medicine, Bunkyo-ku, Tokyo, Japan.
Purpose: The purpose of this study was to compare the distribution of the coronal plane alignment of the knee (CPAK) phenotype between the healthy population and the arthritic population in Japan.
Methods: The retrospective cross-sectional study included 1049 knees. There were 256 healthy individuals with a total of 512 knees and 310 individuals with a total of 537 arthritic knees who underwent around-knee osteotomy between June 2010 and January 2024.
Knee
January 2025
Department of Radiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Background: Long-leg alignment and joint line obliquity have traditionally been assessed using two-dimensional (2D) radiography, but the accuracy of this measurement has remained unclear. This study aimed to evaluate the accuracy of 2D measurements of lateral distal femoral angle (LDFA) and medial proximal tibial angle (MPTA) using upright three-dimensional (3D) computed tomography (CT).
Methods: This study involved 66 knees from 38 patients (34 women, four men) with knee osteoarthritis (OA), categorized by Kellgren-Lawrence (KL) grade.
Jpn J Clin Oncol
January 2025
Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori, Miyagi 981-1293, Japan.
A Japanese woman with Li-Fraumeni syndrome in her 40s underwent comprehensive genetic profiling accompanied by germline data using the Oncoguide NCC Oncopanel, but no germline pathogenic variants in the tumor suppressor gene TP53 were detected. However, careful examination of additional data in the report suggested the presence of a large TP53 deletion. Custom targeting next-generation sequencing and nanopore sequencing revealed a 3.
View Article and Find Full Text PDFEndocrine
January 2025
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy.
Purpose: To compare functional deficits associated to surgery with those caused by the growth of the head and neck paragangliomas (HNPGLs).
Methods: 72 patients with HNPGLs were included. Patients were divided in group A (49 patients undergoing surgery) and group B (23 patients following a wait and see approach).
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